ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Cutting edge: Inhibition of NF-kappaB-mediated TSLP expression by retinoid X receptor.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Thymic stromal lymphopoietin in leukemia: A double-edged sword?Leukemia research reports · 2025Review
- Novel Perspectives of TSLP and RXR Signaling in Corticosteroid-Resistant Asthma: Updates on TSLP Blockers.Current medicinal chemistry · 2025Review
- A four-part guide to lung immunology: Invasion, inflammation, immunity, and intervention.Frontiers in immunology · 2023Review
- A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder.Cellular signalling · 2021Article
- Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.Bioscience reports · 2021Article
- Oscillating lncRNATheranostics · 2021Article
- TSLP Production in the Human Infant Airway Epithelium and Clinical Relevance during Viral Respiratory Infections.American journal of respiratory cell and molecular biology · 2020Article
- Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers.Journal of natural medicines · 2019Article
- Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis.The Journal of investigative dermatology · 2017Article
- The importance of TSLP in allergic disease and its role as a potential therapeutic target.Expert review of clinical immunology · 2014Review
- Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex.The Journal of biological chemistry · 2014Article
- Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes.Hepatology (Baltimore, Md.) · 2013Article
- The biology of thymic stromal lymphopoietin (TSLP).Advances in pharmacology (San Diego, Calif.) · 2013Review
- Respiratory syncytial virus induces functional thymic stromal lymphopoietin receptor in airway epithelial cells.Journal of inflammation research · 2013Article
- Thymic stromal lymphopoietin is induced by respiratory syncytial virus-infected airway epithelial cells and promotes a type 2 response to infection.The Journal of allergy and clinical immunology · 2012Article
- Thymic stromal lymphopoietin and allergic disease.The Journal of allergy and clinical immunology · 2012Review
- Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.The Journal of experimental medicine · 2012Article
- The multiple facets of thymic stromal lymphopoietin (TSLP) during allergic inflammation and beyond.Journal of leukocyte biology · 2012Review
- Functions of thymic stromal lymphopoietin in immunity and disease.Immunologic research · 2012Review
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
The epithelial-derived cytokine thymic stromal lymphopoietin (TSLP) has important roles in the initiation of allergic airway inflammation and the activation of dendritic cells. We have shown that the human TSLP gene is regulated in a NF-kappaB-dependent manner; however the factors that negatively regulate TSLP expression are not known. In this study we demonstrate that 9-cis-retinoic acid (9-cis-RA) is a negative regulator of TSLP expression in airway epithelial cells. This inhibition is manifested as a block in the IL-1beta-mediated recruitment of NF-kappaB to the human TSLP promoter. 9-cis-RA-mediated inhibition is not restricted to TSLP gene expression but rather reflects a general inhibition of NF-kappaB activation, as other NF-kappaB-regulated-genes were also inhibited in a similar manner by 9-cis-RA treatment. Taken as a whole, these data demonstrate that inhibition of IL-1beta-dependent genes by active retinoid X receptors involves antagonism of NF-kappaB signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.