ArticleThe American journal of pathology2008
Conversion of the nipple to hair-bearing epithelia by lowering bone morphogenetic protein pathway activity at the dermal-epidermal interface.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Sweat gland development requires an eccrine dermal niche and couples two epidermal programs.Developmental cell · 2024Article
- Evo Devo of the Vertebrates Integument.Journal of developmental biology · 2023Review
- Best practices to quantify the impact of reproductive toxicants on development, function, and diseases of the rodent mammary gland.Reproductive toxicology (Elmsford, N.Y.) · 2022Review
- Prostatic metaplasia and pilar differentiation in gender-affirming mastectomy specimens.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Parallels in signaling between development and regeneration in ectodermal organs.Current topics in developmental biology · 2022Article
- AOP key event relationship report: Linking androgen receptor antagonism with nipple retention.Current research in toxicology · 2022Review
- Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology.PloS one · 2022Article
- Repeated mutation of a developmental enhancer contributed to human thermoregulatory evolution.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- On the Use and Interpretation of Areola/Nipple Retention as a Biomarker for Anti-androgenic Effects in Rat Toxicity Studies.Frontiers in toxicology · 2021Review
- Defining Key Genes Regulating Morphogenesis of Apocrine Sweat Gland in Sheepskin.Frontiers in genetics · 2018Article
- Functional role of airflow-sensing hairs on the bat wing.Journal of neurophysiology · 2017Article
- Spatiotemporal antagonism in mesenchymal-epithelial signaling in sweat versus hair fate decision.Science (New York, N.Y.) · 2016Article
- The Study on Biological Function of Keratin 26, a Novel Member of Liaoning Cashmere Goat Keratin Gene Family.PloS one · 2016Article
- Deciphering principles of morphogenesis from temporal and spatial patterns on the integument.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Somatosensory substrates of flight control in bats.Cell reports · 2015Article
- Cidea control of lipid storage and secretion in mouse and human sebaceous glands.Molecular and cellular biology · 2014Article
- Sweat gland progenitors in development, homeostasis, and wound repair.Cold Spring Harbor perspectives in medicine · 2014Review
- Mammary stroma in development and carcinogenesis.Journal of mammary gland biology and neoplasia · 2013Review
- Evo-devo of the mammary gland.Journal of mammary gland biology and neoplasia · 2013Review
- The nipple: a simple intersection of mammary gland and integument, but focal point of organ function.Journal of mammary gland biology and neoplasia · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Epithelial appendages, such as mammary glands and hair, arise as a result of epithelial-mesenchymal interactions. Bone morphogenetic proteins (BMPs) are important for hair follicle morphogenesis and cycling and are known to regulate a wide variety of developmental processes. For example, overexpression of BMPs inhibits hair follicle formation. We hypothesized that the down-regulation of the BMP signaling pathway in the basal epidermis expands regions that are competent to form hair follicles and could alter the fate of the epithelium in the mouse nipple to a hair-covered epidermal phenotype. To test our hypothesis, we used a transgenic mouse model in which keratin 14 (KRT14) promoter-mediated overexpression of Noggin, a BMP antagonist, modulates BMP activity. We observed the conversion of nipple epithelium into pilosebaceous units. During normal mammary gland organogenesis, BMPs are likely used by the nipple epithelium to suppress keratinocyte differentiation, thus preventing the formation of pilosebaceous units. In this report, we characterize the morphology and processes that influence the development of hairs within the nipple of the KRT14-Noggin mouse. We demonstrate that Noggin acts, in part, by reducing the BMP signal in the epithelium. Reduction of the BMP signal in turn leads to a reduction in the levels of parathyroid hormone-related protein. We propose that during evolution of the nipple, the BMP pathway was co-opted to suppress hair follicle formation and create a more functional milk delivery apparatus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.