ArticleThe Journal of physiology2008
Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Model-based design of subthalamic nucleus neurons using hybrid optimization.Journal of neurophysiology · 2026Article
- Optimization of an anatomically and electrically detailed rodent subthalamic nucleus neuron model.Journal of neurophysiology · 2024Article
- Differences in action potential propagation speed and axon initial segment plasticity between neurons from Sprague-Dawley rats and C57BL/6 mice.Zoological research · 2022Article
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Maladaptive Downregulation of Autonomous Subthalamic Nucleus Activity following the Loss of Midbrain Dopamine Neurons.Cell reports · 2019Article
- An Electrochemical Study on the Effect of Metal Chelation and Reactive Oxygen Species on a Synthetic Neuromelanin Model.Frontiers in bioengineering and biotechnology · 2019Article
- Axonal Computations.Frontiers in cellular neuroscience · 2019Review
- Accelerated Development of the First-Order Central Auditory Neurons With Spontaneous Activity.Frontiers in molecular neuroscience · 2018Article
- Neurons with Multiple Axons Have Functional Axon Initial Segments.Neuroscience bulletin · 2017Article
- Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons.eLife · 2017Article
- Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons.Neuron · 2017Article
- Article
- Implantable microcoils for intracortical magnetic stimulation.Science advances · 2016Article
- NMDA Receptors Containing the GluN2D Subunit Control Neuronal Function in the Subthalamic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Suppression of subthalamic nucleus activity by micromagnetic stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2015Article
- Intrinsically active and pacemaker neurons in pluripotent stem cell-derived neuronal populations.Stem cell reports · 2014Article
- Structural tuning and plasticity of the axon initial segment in auditory neurons.The Journal of physiology · 2012Review
- Biophysical basis of the phase response curve of subthalamic neurons with generalization to other cell types.Journal of neurophysiology · 2012Article
- Axonal bleb recording.Neuroscience bulletin · 2012Review
- Targeted axon-attached recording with fluorescent patch-clamp pipettes in brain slices.Nature protocols · 2012Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The activity of the subthalamic nucleus (STN) is intimately related to movement and is generated, in part, by voltage-dependent Na(+) (Na(v)) channels that drive autonomous firing. In order to determine the principles underlying the initiation and propagation of action potentials in STN neurons, 2-photon laser scanning microscopy was used to guide tight-seal whole-cell somatic and loose-seal cell-attached axonal/dendritic patch-clamp recordings and compartment-selective ion channel manipulation in rat brain slices. Action potentials were first detected in a region that corresponded most closely to the unmyelinated axon initial segment, as defined by Golgi and ankyrin G labelling. Following initiation, action potentials propagated reliably into axonal and somatodendritic compartments with conduction velocities of approximately 5 m s(-1) and approximately 0.7 m s(-1), respectively. Action potentials generated by neurons with axons truncated within or beyond the axon initial segment were not significantly different. However, axon initial segment and somatic but not dendritic or more distal axonal application of low [Na(+)] ACSF or the selective Na(v) channel blocker tetrodotoxin consistently depolarized action potential threshold. Finally, somatodendritic but not axonal application of GABA evoked large, rapid inhibitory currents in concordance with electron microscopic analyses, which revealed that the somatodendritic compartment was the principal target of putative inhibitory inputs. Together the data are consistent with the conclusions that in STN neurons the axon initial segment and soma express an excess of Na(v) channels for the generation of autonomous activity, while synaptic activation of somatodendritic GABA(A) receptors regulates the axonal initiation of action potentials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.