ArticleProceedings of the National Academy of Sciences of the United States of America2008
Jellyfish vision starts with cAMP signaling mediated by opsin-G(s) cascade.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 190 citations in OpenAlex.
- The first chromosome-level cubozoan genome differentiates unique and common features in different cnidarian lineages.BMC biology · 2026Article
- Multiple opsin expression in cubozoan ocelli indicates functional redundancy.Scientific reports · 2026Article
- Dragonfly red opsins share a common tuning mechanism with mammalian red opsins and further enhancement of near-infrared sensitivity.Cellular and molecular life sciences : CMLS · 2026Article
- Article
- Genome assembly of Bougainvillia cf. muscus (Cnidaria: Hydrozoa).G3 (Bethesda, Md.) · 2025Article
- Comparative Analysis of Convergent Jellyfish Eyes Reveals Extensive Differences in Expression of Vision-Related Genes.Ecology and evolution · 2025Article
- Phototaxis is a satiety-dependent behavioral sequence in Hydra vulgaris.The Journal of experimental biology · 2024Article
- Phototactic preference and its genetic basis in the planulae of the colonial HydrozoanbioRxiv : the preprint server for biology · 2024Article
- Larval swimming in the sea anemoneEcology and evolution · 2024Article
- Light-Mediated Enhancement of Glucose-Stimulated Insulin Release of Optogenetically Engineered Human Pancreatic Beta-Cells.ACS synthetic biology · 2024Article
- Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Functional characterization of four opsins and two G alpha subtypes co-expressed in the molluscan rhabdomeric photoreceptor.BMC biology · 2023Article
- Nematostella vectensis exemplifies the exceptional expansion and diversity of opsins in the eyeless Hexacorallia.EvoDevo · 2023Article
- A visual opsin from jellyfish enables precise temporal control of G protein signalling.Nature communications · 2023Article
- Multiple opsins in a reef-building coral, Acropora millepora.Scientific reports · 2023Article
- Unusual phototransduction via cross-motif signaling from GProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals.Cells · 2022Review
- The diversity of invertebrate visual opsins spanning Protostomia, Deuterostomia, and Cnidaria.Developmental biology · 2022Review
- High-performance optical control of GPCR signaling by bistable animal opsins MosOpn3 and LamPP in a molecular property-dependent manner.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression of a homologue of a vertebrate non-visual opsin Opn3 in the insect photoreceptors.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light sensing starts with phototransduction in photoreceptor cells. The phototransduction cascade has diverged in different species, such as those mediated by transducin in vertebrate rods and cones, by G(q)-type G protein in insect and molluscan rhabdomeric-type visual cells and vertebrate photosensitive retinal ganglion cells, and by G(o)-type G protein in scallop ciliary-type visual cells. Here, we investigated the phototransduction cascade of a prebilaterian box jellyfish, the most basal animal having eyes containing lens and ciliary-type visual cells similar to vertebrate eyes, to examine the similarity at the molecular level and to obtain an implication of the origin of the vertebrate phototransduction cascade. We showed that the opsin-based pigment functions as a green-sensitive visual pigment and triggers the G(s)-type G protein-mediated phototransduction cascade in the ciliary-type visual cells of the box jellyfish lens eyes. We also demonstrated the light-dependent cAMP increase in the jellyfish visual cells and HEK293S cells expressing the jellyfish opsin. The first identified prebilaterian cascade was distinct from known phototransduction cascades but exhibited significant partial similarity with those in vertebrate and molluscan ciliary-type visual cells, because all involved cyclic nucleotide signaling. These similarities imply a monophyletic origin of ciliary phototransduction cascades distributed from prebilaterian to vertebrate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.