ArticleBlood2009
Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis.
Article in Blood, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Viremic non-progression in HIV/SIV infection: A tied game between virus and host.Cell reports. Medicine · 2025Review
- Review
- Stem-like T cells and niches: Implications in human health and disease.Frontiers in immunology · 2022Review
- Bone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis.JCI insight · 2020Article
- Commentary: Maintenance of CD8Frontiers in immunology · 2018Article
- Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis.Journal of virology · 2016Article
- Bone Marrow T Cells and the Integrated Functions of Recirculating and Tissue-Resident Memory T Cells.Frontiers in immunology · 2016Review
- New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression.Journal of immunology research · 2015Review
- CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.PLoS pathogens · 2014Article
- CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure.Immunological reviews · 2013Review
- Multifunctional double-negative T cells in sooty mangabeys mediate T-helper functions irrespective of SIV infection.PLoS pathogens · 2013Article
- Natural SIV hosts: showing AIDS the door.Science (New York, N.Y.) · 2012Review
- Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.The Journal of clinical investigation · 2011Article
- Low levels of SIV infection in sooty mangabey central memory CD⁴⁺ T cells are associated with limited CCR5 expression.Nature medicine · 2011Article
- Early divergent host responses in SHIVsf162P3 and SIVmac251 infected macaques correlate with control of viremia.PloS one · 2011Article
- Limited CD4+ T cell proliferation leads to preservation of CD4+ T cell counts in SIV-infected sooty mangabeys.Proceedings. Biological sciences · 2010Article
- Article
- Article
- Ki-67 staining for determination of rhesus macaque T cell proliferative responses ex vivo.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010Article
- The role of T cells in osteoporosis, an update.International journal of clinical and experimental pathology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Bone marrow (BM) is the key hematopoietic organ in mammals and is involved in the homeostatic proliferation of memory CD8(+) T cells. Here we expanded on our previous observation that BM is a preferential site for T-cell proliferation in simian immunodeficiency virus (SIV)-infected sooty mangabeys (SMs) that do not progress to AIDS despite high viremia. We found high levels of mature T-cell proliferation, involving both naive and memory cells, in healthy SMs and rhesus macaques (RMs). In addition, we observed in both species that lineage-specific, BM-based T-cell proliferation follows antibody-mediated in vivo CD4(+) or CD8(+) T-cell depletion, thus indicating a role for the BM in maintaining T-cell homeostasis under depleting circumstances. We also observed that, in SIV-infected SMs, but not RMs, the level of proliferation of BM-based CD4(+) T cells is higher than that of circulating CD4(+) T cells. Interestingly, limited BM-based CD4(+) T-cell proliferation was found in SIV-infected SMs with low CD4(+) T-cell counts, suggesting a regenerative failure in these animals. Collectively, these results indicate that BM is involved in maintaining T-cell homeostasis in primates and suggest a role for BM-based CD4(+) T-cell proliferation in determining the benign nature of natural SIV infection of SMs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.