Evidence map›Paper›PMID 18832063›Full record

ReviewGenes & development2008

Deconstructing meiosis one kinase at a time: polo pushes past pachytene.

Nancy M Hollingsworth

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Nancy M HollingsworthDepartment of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, New York 11794, USA. nhollin@ms.cc.sunnysb.edu
Stony Brook University · US

Funding

ANALYSIS OF MEIOTIC CHROMOSOME SYNAPSIS IN YEASTR01GM050717 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI HOLLINGSWORTH, NANCY M. · 1995 to 2020
$8.0M
NIGMS NIH HHS R01 GM050717NIGMS NIH HHS R01 GM50717
6 · The paper itself

Abstract

The transition from pachytene to Meiosis I is a key regulatory point in yeast meiosis. This transition requires Ndt80, a transcription factor that commits cells to complete meiosis by expression of a diverse set of genes. In this issue of Genes & Development, Sourirajan and Lichten (2627-2632) report that CDC5, an NDT80-regulated gene encoding yeast polo-like kinase, is sufficient for Holliday junction resolution and exit from pachytene. Determining the meiotic targets of Cdc5 therefore provides a new approach for identifying a eukaryotic Holliday resolvase.

Indexed as

Cell Cycle ProteinsChromosomes, FungalDNA-Binding ProteinsGenes, FungalMeiosisModels, BiologicalPachytene StageProtein KinasesProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription FactorsCDC5 protein, S cerevisiaeCell Cycle ProteinsDNA-Binding ProteinsNDT80 protein, S cerevisiaeProtein KinasesProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsTranscription Factors

Identifiers

PMID18832063
PMCPMC2751021
OpenAlexW2151250269

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.