ArticleThe Journal of infectious diseases2008
CD4+ T helper cell responses against human bocavirus viral protein 2 viruslike particles in healthy adults.
Article in The Journal of infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 35 citations in OpenAlex.
- Differential Interactions of Tissue-Restricted Host Proteins SPLUNC1 and VAMP8 with VP3 of Human Bocaviruses 1 and 2.Pathogens (Basel, Switzerland) · 2026Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- Human bocavirus: Current knowledge and future challenges.World journal of gastroenterology · 2016Review
- Seroepidemiology of human bocaviruses 1 and 2 in China.PloS one · 2015Article
- Detection of human bocavirus 3 in China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2011Article
- Déjà vu all over again: Koch's postulates and virology in the 21st century.The Journal of infectious diseases · 2010Article
- Correlation between bocavirus infection and humoral response, and co-infection with other respiratory viruses in children with acute respiratory infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2010Article
- High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy.Journal of clinical microbiology · 2009Article
- Clinical and epidemiological aspects of human bocavirus infection.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman bocavirus (HBoV) was recently described as a new member of the Parvoviridae family, and its possible association with respiratory illness in infants has been discussed. To date, HBoV genomes have been detected worldwide in respiratory tract samples obtained from children with pulmonary diseases, whereas only limited data on virus-specific immunity are available, mainly because of the lack of recombinant viral antigens.
methodsHBoV viruslike particles (VLPs) were produced in insect cells and characterized by electron microscopy and cesium chloride gradient centrifugation. HBoV viral protein 2 (VP2)-specific antibodies and CD4+ T helper cell responses were analyzed by enzyme-linked immunosorbent assay and enzyme-linked immunospot assay.
resultsVP2 capsid proteins of HBoV were produced in insect cells infected with a recombinant baculovirus, and the formation of icosahedral VLPs (diameter, 21-25 nm; sedimentation density, 1.33 g/cm(3)) was demonstrated. A significant increase in secretion of VP2-specific interferon-gamma was detected in cultures of peripheral blood mononuclear cells obtained from 69 healthy adults found to be positive for HBoV-specific immunoglobulin G antibodies, compared with control stimulations. In parallel, T cell responses against identically expressed parvovirus B19 VP2 VLPs were frequently observed in the individuals studied, without there being obvious cross-reactions between HBoV and parvovirus B19.
conclusionsData suggest the presence of HBoV-specific immune responses in adults and strongly support a high prevalence of HBoV among humans.
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Registered trials
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