ArticleTissue engineering. Part A2009
Effects of temporal hydrostatic pressure on tissue-engineered bovine articular cartilage constructs.
Article in Tissue engineering. Part A, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Temporal Enzymatic Treatment to Enhance the Remodeling of Multiple Cartilage Microtissues into a Structurally Organized Tissue.Advanced healthcare materials · 2024Article
- Regulation of chondrocyte biosynthetic activity by dynamic hydrostatic pressure: the role of TRP channels.Connective tissue research · 2022Article
- A Novel Bioreactor System Capable of Simulating theTissue engineering. Part C, Methods · 2020Article
- A Guide for Using Mechanical Stimulation to Enhance Tissue-Engineered Articular Cartilage Properties.Tissue engineering. Part B, Reviews · 2018Review
- Using Costal Chondrocytes to Engineer Articular Cartilage with Applications of Passive Axial Compression and Bioactive Stimuli.Tissue engineering. Part A · 2018Article
- A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage.Scientific reports · 2017Article
- Cell-based tissue engineering strategies used in the clinical repair of articular cartilage.Biomaterials · 2016Review
- Articular cartilage tissue engineering: the role of signaling molecules.Cellular and molecular life sciences : CMLS · 2016Review
- Cartilage immunoprivilege depends on donor source and lesion location.Acta biomaterialia · 2015Article
- ERK activation is required for hydrostatic pressure-induced tensile changes in engineered articular cartilage.Journal of tissue engineering and regenerative medicine · 2015Article
- Emergence of scaffold-free approaches for tissue engineering musculoskeletal cartilages.Annals of biomedical engineering · 2015Review
- Digoxin and adenosine triphosphate enhance the functional properties of tissue-engineered cartilage.Tissue engineering. Part A · 2015Article
- Harnessing biomechanics to develop cartilage regeneration strategies.Journal of biomechanical engineering · 2015Review
- Biomechanical evaluation of suture-holding properties of native and tissue-engineered articular cartilage.Biomechanics and modeling in mechanobiology · 2015Article
- Promoting increased mechanical properties of tissue engineered neocartilage via the application of hyperosmolarity and 4α-phorbol 12,13-didecanoate (4αPDD).Journal of biomechanics · 2014Article
- Infrapatellar fat pad-derived stem cells maintain their chondrogenic capacity in disease and can be used to engineer cartilaginous grafts of clinically relevant dimensions.Tissue engineering. Part A · 2014Article
- A comparison of self-assembly and hydrogel encapsulation as a means to engineer functional cartilaginous grafts using culture expanded chondrocytes.Tissue engineering. Part C, Methods · 2014Article
- TRPV4 channel activation improves the tensile properties of self-assembled articular cartilage constructs.Acta biomaterialia · 2013Article
- Inducing articular cartilage phenotype in costochondral cells.Arthritis research & therapy · 2013Article
- Self-organization and the self-assembling process in tissue engineering.Annual review of biomedical engineering · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The objective of this study was to determine the effects of temporal hydrostatic pressure (HP) on the properties of scaffoldless bovine articular cartilage constructs. The study was organized in three phases: First, a suitable control for HP application was identified. Second, 10 MPa static HP was applied at three different timepoints (6-10 days, 10-14 days, and 14-18 days) to identify a window in construct development when HP application would be most beneficial. Third, the temporal effects of 10-14-day static HP application, as determined in phase II, were assessed at 2, 4, and 8 weeks. Compressive and tensile mechanical properties, GAG and collagen content, histology for GAG and collagen, and immunohistochemistry for collagen types I and II were assessed. When a culture control identified in phase I was used in phase II, HP application from 10 to 14 days resulted in a significant 1.4-fold increase in aggregate modulus, accompanied by an increase in GAG content, while HP application at all timepoints enhanced tensile properties and collagen content. In phase III, HP had an immediate effect on GAG content, collagen content, and compressive stiffness, while there was a delayed increase in tensile stiffness. The enhanced tensile stiffness was still present at 8 weeks. For the first time, this study examined the immediate and long-term effects of HP on biomechanical properties, and demonstrated that HP has an optimal application time in construct development. These findings are exciting as HP stimulation allowed for the formation of robust tissue-engineered cartilage; for example, 10 MPa static HP resulted in an aggregate modulus of 273 +/- 123 kPa, a Young's modulus of 1.6 +/- 0.4 MPa, a GAG/wet weight of 6.1 +/- 1.4%, and a collagen/wet weight of 10.6 +/- 2.4% at 4 weeks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.