Evidence map›Paper›PMID 18831071›Full record

Trial reportInflammatory bowel diseases2009

Profile of depression in adolescents with inflammatory bowel disease: implications for treatment.

Eva Szigethy, Anna E Craig, Emily A Iobst, Richard J Grand, David Keljo, David DeMaso, Robert Noll

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Inflammatory bowel diseases, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01781481 (The Pediatric Intermed), which is not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
8.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01781481 completednot on this mapstarted 2010, after this paper: background citation

The Pediatric Intermed: A New Clinical Decision Making Tool for Proactive Evaluation of Psychosocial Stress in Children With Inflammatory Bowel Disease

TypeobservationalSponsorChildren's Hospital of Eastern OntarioRan2010 to 2014Enrolled148ConditionsInflammatory Bowel Disease
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.

  1. Psychological interventions for treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Guideline
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Depression subtypes in pediatric inflammatory bowel disease.Journal of pediatric gastroenterology and nutrition · 2014
    Article
  13. Article
  14. Stability of Emotional and Behavioral Functioning in Youth with Inflammatory Bowel Disease.Children's health care : journal of the Association for the Care of Children's Health · 2014
    Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eva SzigethyChildren's Hospital of Pittsburgh/University of Pittsburgh Medical Center, Department of Psychiatry, Pittsburgh, PA 15213, USA. DeSoto Wing, Pittsburgh, PA 15213, USA. szigethye@upmc.edu
Anna E Craig
Emily A Iobst
Richard J Grand
David Keljo
David DeMaso
Robert Noll
Children's Hospital of Pittsburgh · USBoston Children's Hospital · USUniversity of Pittsburgh Medical Center · US

Funding

WIRELESS CAPSULE ENDOSCOPY TO EVALUATE THE SMALL INTESTINE M01RR002172 · NCRR · CHILDREN'S HOSPITAL BOSTON · PI MANDELL, JAMES WILLIAM · 1985 to 2008
$16.0M
Reducing Depressive Symptoms in Physically Ill YouthR01MH077770 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEMASO, DAVID R, SZIGETHY, EVA M · 2008 to 2012
$3.2M
Treatment of Depressed Adolescents with Physical IllnessK23MH064604 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SZIGETHY, EVA M · 2002 to 2006
$823k
NCRR NIH HHS M01 RR002172NCRR NIH HHS M01RR002172NIMH NIH HHS K23 MH064604NIMH NIH HHS K-23 MH064604NIMH NIH HHS R01 MH077770
6 · The paper itself

Abstract

backgroundThe purpose was to determine the utility of including neurovegetative symptoms in assessments of depression in youth with inflammatory bowel disease (IBD).

methodsForty-one youth with IBD and concurrent depressive symptomatology were enrolled in an intervention trial and received either 9 modules of cognitive-behavioral therapy (PASCET-PI) or treatment as usual (TAU). Youth and their primary caregivers completed the Children's Depression Inventory (CDI) at pre- (T1) and posttreatment (T2). Disease severity measures and current steroid dosage were obtained at each timepoint. Change in the individual items of the CDI was compared across groups and examined in association with change in physical illness course.

resultsPaired sample t-tests revealed significant changes in CDI item scores from T1 to T2 for a majority of the depressive symptoms assessed in the PASCET-PI group, but not for the TAU group. These changes did not appear to be linked to changes in disease severity and/or steroid dosage across these same timepoints.

conclusionsThe inclusion of somatic items in the assessment of depression in physically ill youth is important, as these symptoms seem to respond to psychotherapeutic intervention. The present results would suggest that improvements in depressive symptomatology are not solely related to improvements in the course of IBD and that these items do reflect an important part of the profile of depressive symptoms in youth with IBD. Future research is warranted to replicate present findings and explore the generalizability of these results to other pediatric illness populations.

Indexed as

AdolescentAdolescent BehaviorChildCognitive Behavioral TherapyDepressionFemaleGlucocorticoidsHumansInflammatory Bowel DiseasesMalePersonality InventorySeverity of Illness IndexGlucocorticoids

Identifiers

PMID18831071
PMCPMC2638168
OpenAlexW1978009979

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.