ArticleIn vitro cellular & developmental biology. Animal
Culture of endodermal stem/progenitor cells of the mouse tongue.
Article in In vitro cellular & developmental biology. Animal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2025Review
- Cancer Stem Cells in Oral Squamous Cell Carcinoma: A Narrative Review on Experimental Characteristics and Methodological Challenges.Biomedicines · 2024Review
- Cocktail Formula and Application Prospects for Oral and Maxillofacial Organoids.Tissue engineering and regenerative medicine · 2022Review
- Advances of Engineered Hydrogel Organoids within the Stem Cell Field: A Systematic Review.Gels (Basel, Switzerland) · 2022Review
- Immortalization and Characterization of Rat Lingual Keratinocytes in a High-Calcium and Feeder-Free Culture System Using ROCK Inhibitor Y-27632.International journal of molecular sciences · 2021Article
- Onset of taste bud cell renewal starts at birth and coincides with a shift in SHH function.eLife · 2021Article
- A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Oesophagus.Frontiers in cell and developmental biology · 2021Review
- Bovine tongue epithelium-derived cells: A new source of bovine mesenchymal stem cells.Bioscience reports · 2020Article
- Developmental plasticity of epithelial stem cells in tooth and taste bud renewal.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Organoid Culture of Lingual Epithelial Cells in a Three-Dimensional Matrix.Methods in molecular biology (Clifton, N.J.) · 2019Article
- [Development and homeostasis of taste buds in mammals].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2018Article
- Insulin Is Transcribed and Translated in Mammalian Taste Bud Cells.Endocrinology · 2018Article
- Lingual Epithelial Stem Cells and Organoid Culture of Them.International journal of molecular sciences · 2016Review
- Progress and renewal in gustation: new insights into taste bud development.Development (Cambridge, England) · 2015Review
- Developmental Plasticity of Patterned and Regenerating Oral Organs.Current topics in developmental biology · 2015Review
- Developing and regenerating a sense of taste.Current topics in developmental biology · 2015Review
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium.Development (Cambridge, England) · 2014Article
- Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes.Cancer cell international · 2014Article
- Establishment of a novel lingual organoid culture system: generation of organoids having mature keratinized epithelium from adult epithelial stem cells.Scientific reports · 2013Article
- Oral epithelial stem cells in tissue maintenance and disease: the first steps in a long journey.International journal of oral science · 2013Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tongue represents a very accessible source of tissue-specific epithelial stem cells of endodermal origin. However, little is known about the properties of these cells and the mechanisms regulating their proliferation and differentiation. Foxa2, an endodermal marker, is expressed throughout the tongue epithelium during embryonic development but becomes confined to a minority of basal cells and some taste bud sensory cells in the adult tongue. Using a previously described line of transgenic mice in which enhanced green fluorescent protein (eGFP) is expressed under the control of a human keratin 5 promoter region (Krt5-eGFP), we have isolated a subpopulation of cells in the basal epithelial layer of the mouse tongue with a high efficiency of generating holoclones of undifferentiated cells in culture with a feeder layer. Krt5-GFP(hi) cells can both self renew and give rise to differentiated stratified keratinized epithelial cells when cultured on an air-liquid interface.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.