ArticleJournal of bioenergetics and biomembranes2008
A chemically explicit model for the mechanism of proton pumping in heme-copper oxidases.
Article in Journal of bioenergetics and biomembranes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 72 citations in OpenAlex.
- Structural and functional mechanisms of cytochrome c oxidase.Journal of inorganic biochemistry · 2025Review
- Tools for analyzing protonation states and for tracing proton transfer pathways with examples from the Rb. sphaeroides photosynthetic reaction centers.Photosynthesis research · 2023Article
- Protein Motifs for Proton Transfers That Build the Transmembrane Proton Gradient.Frontiers in chemistry · 2021Review
- Redox-Driven Proton Pumps of the Respiratory Chain.Biophysical journal · 2018Article
- Role of conformational change and K-path ligands in controlling cytochromeBiochemical Society transactions · 2017Review
- Protonation-State-Dependent Communication in Cytochrome c Oxidase.Biophysical journal · 2017Article
- RETRACTED: Protonation State-Dependent Communication in Cytochrome c Oxidase.Biophysical journal · 2016Article
- Mutation of a single residue in the ba3 oxidase specifically impairs protonation of the pump site.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Proton translocation in cytochrome c oxidase: insights from proton exchange kinetics and vibrational spectroscopy.Biochimica et biophysica acta · 2015Review
- Characterizing the proton loading site in cytochrome c oxidase.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Biochemistry and theory of proton-coupled electron transfer.Chemical reviews · 2014Review
- Copper active sites in biology.Chemical reviews · 2014Review
- Computational prediction and in vitro analysis of potential physiological ligands of the bile acid binding site in cytochrome c oxidase.Biochemistry · 2013Article
- Functions of the hydrophilic channels in protonmotive cytochrome c oxidase.Journal of the Royal Society, Interface · 2013Review
- A conserved amphipathic ligand binding region influences k-path-dependent activity of cytochrome C oxidase.Biochemistry · 2013Article
- Article
- Product-controlled steady-state kinetics between cytochrome aa(3) from Rhodobacter sphaeroides and equine ferrocytochrome c analyzed by a novel spectrophotometric approach.Biochimica et biophysica acta · 2012Article
- From static structure to living protein: computational analysis of cytochrome c oxidase main-chain flexibility.Biophysical journal · 2012Article
- Exploring the proton pump and exit pathway for pumped protons in cytochrome ba3 from Thermus thermophilus.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Coupled electron and proton transfer reactions during the O→E transition in bovine cytochrome c oxidase.Biochimica et biophysica acta · 2012Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A mechanism for proton pumping is described that is based on chemiosmotic principles and the detailed molecular structures now available for cytochrome oxidases. The importance of conserved water positions and a step-wise gated process of proton translocation is emphasized, where discrete electron transfer events are coupled to proton uptake and expulsion. The trajectory of each pumped proton is the same for all four substrate electrons. An essential role for the His-Tyr cross-linked species is discussed, in gating of the D- and K-channels and as an acceptor/donor of electrons and protons at the binuclear center.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.