ArticleMolecular and cellular biochemistry2009
Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma.
Article in Molecular and cellular biochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Inflammatory Signaling and Endothelial Activation Drive Thrombosis in Hodgkin and Non-Hodgkin Lymphoma.Cells · 2026Article
- Immune and stromal transcriptional patterns that influence the outcome of classic Hodgkin lymphoma.Scientific reports · 2024Article
- Leptin and leptin receptor expression as biomarkers for breast cancer: a retrospective study.BMC cancer · 2023Article
- Review
- Frequency of EBV associated classical Hodgkin lymphoma decreases over a 54-year period in a Brazilian population.Scientific reports · 2018Article
- Detection of Enhancer-Associated Rearrangements Reveals Mechanisms of Oncogene Dysregulation in B-cell Lymphoma.Cancer discovery · 2015Article
- Article
- Article
- FAS/FASL expression profile as a prognostic marker in squamous cell carcinoma of the oral cavity.PloS one · 2013Article
- Increased expression of CD4+CD25 +FOXP3+ regulatory T cells correlates with Epstein-Barr virus and has no impact on survival in patients with classical Hodgkin lymphoma in Brazil.Medical oncology (Northwood, London, England) · 2012Article
- FGFR4 profile as a prognostic marker in squamous cell carcinoma of the mouth and oropharynx.PloS one · 2012Article
- HIF1-alpha expression predicts survival of patients with squamous cell carcinoma of the oral cavity.PloS one · 2012Article
- Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation.PloS one · 2012Article
- Article
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Authors and funding
5 authors.
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Abstract
Hodgkin and Reed-Sternberg (H-RS) cells of classical Hodgkin lymphoma (cHL) present an impaired expression of immunoglobulin genes, but escape apoptotic death. We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases, whereas NOS3 expression was not detected. Positive associations were found between NOS1 and p53, bax and NOS2, bcl-2 and NOS2, bax and p53, and between bax and fasL. Inverse correlations were established between EBV and NOS2 and between EBV and bcl-2. A shorter overall survival (OS) was associated with strong expression of NOS2. In conclusion, NOS are expressed by H-RS cells of cHL.
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