ArticleEvidence-based complementary and alternative medicine : eCAM2008
Can Vitex Agnus Castus be Used for the Treatment of Mastalgia? What is the Current Evidence?
Article in Evidence-based complementary and alternative medicine : eCAM, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- The effects of titanium dioxide (TiOHeliyon · 2023Article
- Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus.The Plant journal : for cell and molecular biology · 2018Article
- Observational
- Effects of Mastalgia in Young Women on Quality of Life, Depression, and Anxiety Levels.The Indian journal of surgery · 2016Article
- A Randomized Pilot Study of Inositol in Association with Betaine and Boswellia in the Management of Mastalgia and Benign Breast Lump in Premenopausal Women.Breast cancer : basic and clinical research · 2016Article
- Can mastalgia be another somatic symptom in fibromyalgia syndrome?Clinics (Sao Paulo, Brazil) · 2015Article
- A Rare Clinical Entity in the Differential Diagnosis of Mastalgia: Thoracic Zona.The journal of breast health · 2015Article
- Comparison of fructus agni casti and flurbiprofen in the treatment of cyclic mastalgia in premenopausal women.Ulusal cerrahi dergisi · 2014Article
- The genus Vitex: A review.Pharmacognosy reviews · 2013Review
- Compounds from the Fruits of the Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP(H):Quinone Oxidoreductase Type 1 Induction.Evidence-based complementary and alternative medicine : eCAM · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There have been many treatments suggested for the management of mastalgia; one of these is the fruit extract of Vitex Agnus castus L. commonly known as Agnus castus, an extract of a deciduous shrub native to Mediterranean Europe and Central Asia. It is postulated that A. castus suppresses the stress-induced latent hyperprolactinemia which is a release of supra-physiological levels of prolactin in some patients in response to stressful stimuli. It is postulated that A. castus could be effective in the treatment of cyclical mastalgia by inhibiting the release of excess prolactin by blocking Dopamine-2 receptor type on pituitary. The adverse events following A. castus treatment are mild and reversible. The aim of this review is assess the efficacy of A. castus in the treatment of mastalgia. Data from randomized and non-randomized studies regarding the efficacy and safety of A. castus is reviewed in a systematic fashion. It is concluded that A. castus can be considered as an efficient alternative phytotherapeutic agent in the treatment of mastalgia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.