ArticleInternational journal of clinical and experimental pathology2009
Decreased survival and hepato-renal pathology in mice with C-terminally truncated GP73 (GOLPH2).
Article in International journal of clinical and experimental pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Golgi protein GOLM1 is a tissue and urine biomarker of prostate cancer.Neoplasia (New York, N.Y.) · 2008Pooled it
- Serum and urinary golgi membrane protein 1 (GOLM1/GP73/G73) for chronic kidney disease staging.Frontiers in medicine · 2026Article
- Golgi protein 73: charting new territories in diagnosing significant fibrosis in MASLD: a prospective cross-sectional study.Frontiers in endocrinology · 2024Article
- Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis.ACS nano · 2023Article
- Short-term prognostic factors for hepatitis B virus-related acute-on-chronic liver failure.World journal of clinical cases · 2022Article
- Recent advances of GOLM1 in hepatocellular carcinoma.Hepatic oncology · 2020Review
- Serum GP73 - An Additional Biochemical Marker for Liver Inflammation in Chronic HBV Infected Patients with Normal or Slightly Raised ALT.Scientific reports · 2019Article
- [Diagnostic application of serum GP73 and the relevant mechanism in the diagnosis of liver cirrhosis].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2018Article
- Research progress on GP73 in malignant tumors.OncoTargets and therapy · 2018Review
- GP73 level determines chemotherapeutic resistance in human hepatocellular carcinoma cells.Journal of Cancer · 2018Article
- GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction.Scientific reports · 2017Article
- Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion.British journal of cancer · 2015Article
- Serum Golgi protein 73 levels and liver pathological grading in cases of chronic hepatitis B.Molecular medicine reports · 2015Article
- Serum Golgi protein 73 (GP73) is a diagnostic and prognostic marker of chronic HBV liver disease.Medicine · 2015Article
- Epithelium-Specific ETS (ESE)-1 upregulated GP73 expression in hepatocellular carcinoma cells.Cell & bioscience · 2014Article
- Expression and prognostic significance of golgiglycoprotein73 (GP73) with epithelial-mesenchymal transition (EMT) related molecules in hepatocellular carcinoma (HCC).Diagnostic pathology · 2013Article
- GP73 is a potential marker for evaluating AIDS progression and antiretroviral therapy efficacy.Molecular biology reports · 2013Article
- GP73 is down-regulated in gastric cancer and associated with tumor differentiation.World journal of surgical oncology · 2013Article
- Serum GP73, a marker for evaluating progression in patients with chronic HBV infections.PloS one · 2013Article
- Golgi phosphoprotein 2 in physiology and in diseases.Cell & bioscience · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GP73 (Golph2) is a type II Golgi-localized integral membrane protein that is normally expressed in epithelial cells of many human tissues, and that is highly upregulated in liver disease. While its function is unknown, the GP73 C-terminus contains putative protein-interaction domains. We used a gene trap approach to generate mice with a severe truncation of the GP73 C-terminus (GP73(tr/tr)) in order to investigate the physiological role of this protein. GP73(tr/tr) mice were born at the expected rate and were fertile, but cumulative survival was significantly reduced compared to wild-type controls, particularly in females. GP73(tr/tr) mice developed varying degrees of renal disease, most notably focal segmental glomerulosclerosis and hyaline thrombi. In addition to renal abnormalities, GP73(tr/tr) mice developed marked microvesicular hepatic steatosis, hepatocyte nuclear membrane irregularities and intranuclear inclusions. GP73(tr/tr) expression in morphologically normal kidneys and livers was constitutively low, but was strikingly upregulated in the diseased kidney cortex, and was upregulated in livers in animals of advanced age. Despite the substantial morphological changes in the kidneys and liver, routine screening serum assays provided no evidence of renal or hepatic dysfunction. Consequently, the cause of the increased mortality of GP73(tr/tr) animals is unclear at present. Our study indicates that GP73 is essential for normal survival, and suggests multiple roles for GP73 in epithelial cell function in the kidney and liver.
Indexed as
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18830387PMC2491393What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.