ArticleJournal of human hypertension2009
Association between renin-angiotensin system gene polymorphism and essential hypertension: a community-based study.
Article in Journal of human hypertension, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Association BetweenInternational journal of environmental research and public health · 2026Pooled it
- Pooled it
- A-6G and A-20C polymorphisms in the angiotensinogen promoter and hypertension risk in Chinese: a meta-analysis.PloS one · 2011Pooled it
- Association between angiotensin converting enzyme gene polymorphism and essential hypertension: A systematic review and meta-analysis.Journal of the renin-angiotensin-aldosterone system : JRAASPooled it
- The influence of long term hydrochlorothiazide administration on the relationship between renin-angiotensin-aldosterone system activity and plasma glucose in patients with hypertension.Oxidative medicine and cellular longevity · 2013Trial
- Association between Angiotensin-converting enzyme (ACE) insertion/deletion polymorphism and hypertension in a Ghanaian population.PloS one · 2024Article
- No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Article
- Gene Polymorphism and Total Genetic Score in Martial Arts Athletes with Different Athletic Qualifications.Genes · 2022Article
- Analysis of the Pattern, Alliance and Risk of rs1799752 (ACE I/D Polymorphism) with Essential Hypertension.Indian journal of clinical biochemistry : IJCB · 2022Article
- Article
- Analysis of Association of Angiotensin II Type 1 Receptor Gene A1166C Gene Polymorphism with Essential Hypertension.Indian journal of clinical biochemistry : IJCB · 2018Article
- Angiotensin-converting enzyme insertion/deletion polymorphism, 24-h blood pressure profile and left ventricular hypertrophy in hypertensive individuals: a cross-sectional study.European journal of medical research · 2015Article
- Article
- Association of T174M polymorphism of angiotensinogen gene with essential hypertension: A meta-analysis.Genetics and molecular biology · 2014Article
- Angiotensin-converting enzyme gene polymorphism and middle cerebral artery stenosis in a Chinese Han population.Neural regeneration research · 2013Article
- Article
- Renin-angiotensin-aldosterone system genes and nonarteritic anterior ischemic optic neuropathy.Molecular vision · 2011Article
- Variants in genes involved in functional pathways associated with hypertension in African Americans.Clinical and translational science · 2010Article
- Mid-life blood pressure levels and the 8-year incidence of type 2 diabetes mellitus: the Rancho Bernardo Study.Journal of human hypertension · 2010Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renin-angiotensin (RAS) genes, a group of promising candidate genes involved in essential hypertension (EH), play a key role in blood pressure regulation. Recently, a series of novel RAS gene polymorphisms were reported, which significantly influence the rate of the gene transcription. This study was designed to explore the association between the RAS gene polymorphisms and EH in a remote countryside population. We examined six polymorphisms in the main component genes of RAS: angiotensin-converting enzyme (ACE) (I/D), angiotensinogen (AGT) (A-6G, A-20C, G-217A and T174 M) and angiotensin type 1 receptor (AT1R) (A1166C). Six polymorphisms were genotyped by gene chip technology. Association studies were performed in 220 EH patients and 235 normotensives. Our results revealed that AGT A-6G, T174 M and ACE-I/D were significantly associated with EH (AGT A-6G: AG+GG vs AA; OR=1.36; 95% CI=1.04-1.77. T174M: CT+TT vs CC; OR=1.45; 95% CI=1.15-1.90. ACE I/D: ID+DD vs II; OR=1.171; 95% CI=1.00-1.37). Moreover the logistic regression analysis suggested that the haplotype of AGT -6A, 174C, -217G and -20A might decrease the risk of EH (OR=0.64; 95% CI=0.49-0.83), after adjusting the confounding factors of gender, age and BMI. In conclusion, the AGT A-6G, T174 M and ACE I/D polymorphisms are associated with EH and the AGT haplotype -6A, 174C, -217G and -20A decrease the risk of EH in the southern Chinese population.
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