ArticleJournal of neurophysiology2008
Asymmetric operation of the locomotor central pattern generator in the neonatal mouse spinal cord.
Article in Journal of neurophysiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Inhibitory circuits control leg movements duringeLife · 2026Article
- Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025Article
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- Inference technique for the synaptic conductances in rhythmically active networks and application to respiratory central pattern generation circuits.bioRxiv : the preprint server for biology · 2025Article
- Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat.Journal of neurophysiology · 2022Article
- Neuronal Circuits That Control Rhythmic Pectoral Fin Movements in Zebrafish.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Ankle muscle tenotomy does not alter ankle flexor muscle recruitment bias during locomotor-related repetitive limb movement in late-stage chick embryos.Developmental psychobiology · 2018Article
- Synaptic Excitation in Spinal Motoneurons Alternates with Synaptic Inhibition and Is Balanced by Outward Rectification during Rhythmic Motor Network Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Differences in flexor and extensor activity during locomotor-related leg movements in chick embryos.Developmental psychobiology · 2017Article
- Decoding the organization of spinal circuits that control locomotion.Nature reviews. Neuroscience · 2016Review
- Extensor motoneurone properties are altered immediately before and during fictive locomotion in the adult decerebrate rat.The Journal of physiology · 2015Article
- Premotor spinal network with balanced excitation and inhibition during motor patterns has high resilience to structural division.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Article
- Enabling techniques for in vitro studies on mammalian spinal locomotor mechanisms.Frontiers in bioscience (Landmark edition) · 2012Review
- Push-pull control of motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Patterns of presynaptic activity and synaptic strength interact to produce motor output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Contribution of motoneuron intrinsic properties to fictive motor pattern generation.Journal of neurophysiology · 2011Article
- Activation of group I metabotropic glutamate receptors modulates locomotor-related motoneuron output in mice.Journal of neurophysiology · 2011Article
- Synaptic patterning of left-right alternation in a computational model of the rodent hindlimb central pattern generator.Journal of computational neuroscience · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The rhythmic voltage oscillations in motor neurons (MNs) during locomotor movements reflect the operation of the pre-MN central pattern generator (CPG) network. Recordings from MNs can thus be used as a method to deduct the organization of CPGs. Here, we use continuous conductance measurements and decomposition methods to quantitatively assess the weighting and phase tuning of synaptic inputs to different flexor and extensor MNs during locomotor-like activity in the isolated neonatal mice lumbar spinal cord preparation. Whole cell recordings were obtained from 22 flexor and 18 extensor MNs in rostral and caudal lumbar segments. In all flexor and the large majority of extensor MNs the extracted excitatory and inhibitory synaptic conductances alternate but with a predominance of inhibitory conductances, most pronounced in extensors. These conductance changes are consistent with a "push-pull" operation of locomotor CPG. The extracted excitatory and inhibitory synaptic conductances varied between 2 and 56% of the mean total conductance. Analysis of the phase tuning of the extracted synaptic conductances in flexor and extensor MNs in the rostral lumbar cord showed that the flexor-phase-related synaptic conductance changes have sharper locomotor-phase tuning than the extensor-phase-related conductances, suggesting a modular organization of premotor CPG networks consisting of reciprocally coupled, but differently composed, flexor and extensor CPG networks. There was a clear difference between phase tuning in rostral and caudal MNs, suggesting a distinct operation of CPG networks in different lumbar segments. The highly asymmetric features were preserved throughout all ranges of locomotor frequencies investigated and with different combinations of locomotor-inducing drugs. The asymmetric nature of CPG operation and phase tuning of the conductance profiles provide important clues to the organization of the rodent locomotor CPG and are compatible with a multilayered and distributed structure of the network.
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