ArticleJournal of virology2008
Characterization of white spot syndrome virus envelope protein VP51A and its interaction with viral tegument protein VP26.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Review
- Structural modelling and preventive strategy targeting of WSSV hub proteins to combat viral infection in shrimp Penaeus monodon.PloS one · 2024Article
- Interaction of the Small GTPase Cdc42 with Arginine Kinase Restricts White Spot Syndrome Virus in Shrimp.Journal of virology · 2017Article
- Characterization of white spot syndrome virus VP52B and its interaction with VP26.Virus genes · 2015Article
- Hijacking of host calreticulin is required for the white spot syndrome virus replication cycle.Journal of virology · 2014Article
- Characterization and interactome study of white spot syndrome virus envelope protein VP11.PloS one · 2014Article
- Construction and application of a protein interaction map for white spot syndrome virus (WSSV).Molecular & cellular proteomics : MCP · 2014Article
- VP292 of White spot syndrome virus Interacts with VP26.Indian journal of virology : an official organ of Indian Virological Society · 2013Article
- Host and virus protein interaction studies in understanding shrimp virus gene function.Indian journal of virology : an official organ of Indian Virological Society · 2012Article
- Assessment of the roles of copepod Apocyclops royi and bivalve mollusk Meretrix lusoria in white spot syndrome virus transmission.Marine biotechnology (New York, N.Y.) · 2011Article
- A 3D model of the membrane protein complex formed by the white spot syndrome virus structural proteins.PloS one · 2010Article
- Four major envelope proteins of white spot syndrome virus bind to form a complex.Journal of virology · 2009Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we characterize a novel white spot syndrome virus (WSSV) structural protein, VP51A (WSSV-TW open reading frame 294), identified from a previous mass spectrometry study. Temporal-transcription analysis showed that vp51A is expressed in the late stage of WSSV infection. Gene structure analysis showed that the transcription initiation site of vp51A was 135 bp upstream of the translation start codon. The poly(A) addition signal overlapped with the translation stop codon, TAA, and the poly(A) tail was 23 bp downstream of the TAA. Western blot analysis of viral protein fractions and immunoelectron microscopy both suggested that VP51A is a viral envelope protein. Western blotting of the total proteins extracted from WSSV virions detected a band that was close to the predicted 51-kDa mass, but the strongest signal was around 72 kDa. We concluded that this 72-kDa band was in fact the full-length VP51A protein. Membrane topology assays demonstrated that the VP51A 72-kDa protein is a type II transmembrane protein with a highly hydrophobic transmembrane domain on its N terminus and a C terminus that is exposed on the surface of the virion. Coimmunoprecipitation, colocalization, and yeast two-hybrid assays revealed that VP51A associated directly with VP26 and indirectly with VP28, with VP26 acting as a linker protein in the formation of a VP51A-VP26-VP28 complex.
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