ArticleJournal of virology2008
Lymphocytic choriomeningitis virus infection yields overlapping CD4+ and CD8+ T-cell responses.
Article in Journal of virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- CD11a and CD49d enhance the detection of antigen-specific T cells following human vaccination.Vaccine · 2017Trial
- Overlapping MHC class I/II Epitopes Program cDC1-like Differentiation of Monocyte-Derived Dendritic Cells via mTORC1 Signaling Inhibition.bioRxiv : the preprint server for biology · 2026Article
- Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.iScience · 2023Article
- Viral infection reveals hidden sharing of TCR CDR3 sequences between individuals.Frontiers in immunology · 2023Article
- CD4 expression in effector T cells depends on DNA demethylation over a developmentally established stimulus-responsive element.Nature communications · 2022Article
- MHC class I and II peptide homology regulates the cellular immune response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection.The Journal of experimental medicine · 2020Article
- CD4 T Cell Affinity Diversity Is Equally Maintained during Acute and Chronic Infection.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection.Immunology · 2017Article
- Prostate Cancer Immunotherapy: Exploiting the HLA Class II Pathway in Vaccine Design.Journal of clinical & cellular immunology · 2015Article
- Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells.The Journal of experimental medicine · 2015Article
- Cutting edge: T follicular helper cell differentiation is defective in the absence of Bcl6 BTB repressor domain function.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Epitope Prediction Assays Combined with Validation Assays Strongly Narrows down Putative Cytotoxic T Lymphocyte Epitopes.Vaccines · 2015Article
- Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.Science (New York, N.Y.) · 2015Article
- Both positive and negative effects on immune responses by expression of a second class II MHC molecule.Molecular immunology · 2014Article
- Mice of the resistant H-2(b) haplotype mount broad CD4(+) T cell responses against 9 distinct Friend virus epitopes.Virology · 2014Article
- Determining the breadth of the respiratory syncytial virus-specific T cell response.Journal of virology · 2014Article
- Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- CD4(+) T-cell inhibitory ligands: a tool for characterizing dysfunctional CD4(+) T cells during chronic infection.Immunology · 2013Article
- Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Activation of CD4(+) T cells helps establish and sustain other immune responses. We have previously shown that responses against a broad set of nine CD4(+) T-cell epitopes were present in the setting of lymphocytic choriomeningitis virus (LCMV) Armstrong infection in the context of H-2(d). This is quite disparate to the H-2(b) setting, where only two epitopes have been identified. We were interested in determining whether a broad set of responses was unique to H-2(d) or whether additional CD4(+) T-cell epitopes could be identified in the setting of the H-2(b) background. To pursue this question, we infected C57BL/6 mice with LCMV Armstrong and determined the repertoire of CD4(+) T-cell responses using overlapping 15-mer peptides corresponding to the LCMV Armstrong sequence. We confirmed positive responses by intracellular cytokine staining and major histocompatibility complex (MHC)-peptide binding assays. A broad repertoire of responses was identified, consisting of six epitopes. These epitopes originate from the nucleoprotein (NP) and glycoprotein (GP). Out of the six newly identified CD4(+) epitopes, four of them also stimulate CD8(+) T cells in a statistically significant manner. Furthermore, we assessed these CD4(+) T-cell responses during the memory phase of LCMV Armstrong infection and after infection with a chronic strain of LCMV and determined that a subset of the responses could be detected under these different conditions. This is the first example of a broad repertoire of shared epitopes between CD4(+) and CD8(+) T cells in the context of viral infection. These findings demonstrate that immunodominance is a complex phenomenon in the context of helper responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.