Trial reportThe British journal of ophthalmology2009
Corticosteroids for bacterial corneal ulcers.
Trial report in The British journal of ophthalmology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Topical corticosteroids as adjunctive therapy for bacterial keratitis.The Cochrane database of systematic reviews · 2014Pooled it
- The steroids for corneal ulcers trial (SCUT): secondary 12-month clinical outcomes of a randomized controlled trial.American journal of ophthalmology · 2014Trial
- Prior elicitation and Bayesian analysis of the Steroids for Corneal Ulcers Trial.Ophthalmic epidemiology · 2012Trial
- Corticosteroids for bacterial keratitis: the Steroids for Corneal Ulcers Trial (SCUT).Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Trial
- The steroids for corneal ulcers trial: study design and baseline characteristics.Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Trial
- Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment.Investigative ophthalmology & visual science · 2012Trial
- Clinical comparative analysis of culture-proven bacterial keratitis according to prior topical steroid use: a retrospective study in a tertiary referral center of South Korea.Scientific reports · 2023Article
- Urgent unmet needs in the care of bacterial keratitis: An evidence-based synthesis.The ocular surface · 2023Article
- Simultaneous control of infection and inflammation with keratin-derived antibacterial peptides targeting TLRs and co-receptors.Science translational medicine · 2023Article
- A Review of the Categorizations of Mild, Moderate, and Severe Bacterial Keratitis Ulcers and Day-1 Treatment Regimen When Using the Topical Fluoroquinolones 0.3% Ciprofloxacin and 0.3% Ofloxacin.Current therapeutic research, clinical and experimental · 2023Review
- Ocular surface disease in thyroid eye disease: A narrative review.The ocular surface · 2022Review
- Genipin Delays Corneal Stromal Enzymatic Digestion.Translational vision science & technology · 2021Article
- Double-masked, sham and placebo-controlled trial of corneal cross-linking and topical difluprednate in the treatment of bacterial keratitis: Steroids and Cross-linking for Ulcer Treatment Trial (SCUT II) study protocol.BMJ open ophthalmology · 2021Article
- Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis.Frontiers in chemistry · 2021Review
- Update on the Management of Infectious Keratitis.Ophthalmology · 2017Review
- Prednisolone induces apoptosis in corneal epithelial cells through the intrinsic pathway.Scientific reports · 2017Article
- The effects of oral and topical corticosteroid in rabbit corneas.BMC ophthalmology · 2016Article
- Use of adjunctive topical corticosteroids in bacterial keratitis.Current opinion in ophthalmology · 2016Review
- Role of steroids in the treatment of bacterial keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- Efficacy of systemic vitamin C supplementation in reducing corneal opacity resulting from infectious keratitis.Medicine · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
aimsThe aim of the study was to conduct a preliminary clinical trial to assess whether adjunctive topical corticosteroids improve outcomes in bacterial keratitis and, if no difference was found, to determine the feasibility and sample size necessary for conducting a larger trial to answer this question.
methodsIn this single centre, double-masked clinical trial, 42 patients with culture-confirmed bacterial keratitis at Aravind Eye Hospital in India were randomised to receive either topical prednisolone phosphate or placebo. All patients received topical moxifloxacin. The primary outcome was best spectacle-corrected visual acuity (BSCVA) at 3 months, adjusting for enrolment BSCVA and arm. Other pre-specified outcomes included re-epithelialisation time, infiltrate/scar size and adverse events.
resultsCompared with placebo, patients in the steroid group re-epithelialised more slowly (hazard ratio 0.47, 95% CI 0.23 to 0.94). There was no significant difference in BSCVA or infiltrate/scar size at 3 weeks or 3 months. To have 80% power to detect a two-line difference in acuity, 360 cases would be required.
conclusionsAlthough corticosteroid treatment resulted in a statistically significant delay in re-epithelialisation, this did not translate to a significant difference in visual acuity, infiltrate/scar size or adverse events. To assess the effect of steroids on acuity, a larger trial is warranted and feasible.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.