ArticleMolecular human reproduction2008
Calpain5 expression is decreased in endometriosis and regulated by HOXA10 in human endometrial cells.
Article in Molecular human reproduction, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Endometrial biomarkers for the non-invasive diagnosis of endometriosis.The Cochrane database of systematic reviews · 2016Pooled it
- Repercussions of the Calpain Cleavage-Related Missense Mutations in the Cytosolic Domains of Human Integrin-β Subunits on the Calpain-Integrin Signaling Axis.International journal of molecular sciences · 2025Article
- Role of HOXA10 in pathologies of the endometrium.Reviews in endocrine & metabolic disorders · 2025Review
- CAPN5 attenuates cigarette smoke extract-induced apoptosis and inflammation in BEAS-2B cells.Tobacco induced diseases · 2024Article
- Altered Differential Expression of Genes and microRNAs Related to Adhesion and Apoptosis Pathways in Patients with Different Phenotypes of Endometriosis.International journal of molecular sciences · 2023Article
- Integrated analysis of genome-wide gene expression and DNA methylation profiles reveals candidate genes in ovary endometriosis.Frontiers in endocrinology · 2023Article
- The endometrial immune environment of women with endometriosis.Human reproduction update · 2019Review
- Defining the genetic profile of endometriosis.Experimental and therapeutic medicine · 2019Review
- Global Identification of HIF-1α Target Genes in Benzene Poisoning Mouse Bone Marrow Cells.International journal of environmental research and public health · 2018Article
- Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10.Cell death & disease · 2018Article
- Predictive biomarkers may allow precision therapy of endometriosis.Journal of endometriosis and pelvic pain disorders · 2017Article
- Integrative Analysis Reveals Regulatory Programs in Endometriosis.Reproductive sciences (Thousand Oaks, Calif.) · 2015Article
- Calpain 5 is highly expressed in the central nervous system (CNS), carries dual nuclear localization signals, and is associated with nuclear promyelocytic leukemia protein bodies.The Journal of biological chemistry · 2014Article
- Article
- CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity.Reproductive biology and endocrinology : RB&E · 2013Article
- Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model.Endocrinology · 2011Article
- The calpain system and cancer.Nature reviews. Cancer · 2011Review
- GROα regulates human embryonic stem cell self-renewal or adoption of a neuronal fate.Differentiation; research in biological diversity · 2011Article
- Regulation of tryptophan 2,3-dioxygenase by HOXA10 enhances embryo viability through serotonin signaling.American journal of physiology. Endocrinology and metabolism · 2011Article
- Regional development of uterine decidualization: molecular signaling by Hoxa-10.Molecular reproduction and development · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Calpains have been implicated in the regulation of apoptosis. Here, we identified Calpain5 as a target of HOXA10 transcriptional regulation in endometrial cells as well as its aberrant regulation in endometriosis. Histologically confirmed biopsies of endometriosis were obtained from 20 women. Eutopic endometrium was collected by endometrial biopsy from 30 controls and from the 20 subjects with endometriosis. First trimester decidual samples were obtained from five subjects at the time of pregnancy termination. Immunohistochemistry was used to identify Calpain5 expression. Calpain5 was expressed in endometrial stromal and glandular cells throughout the menstrual cycle and in decidua. Calpain5 protein expression was decreased in both stromal and glandular cells from women with endometriosis compared with that of fertile controls. Human endometrial stromal and epithelial cell lines were transfected with pcDNA/HOXA10, HOXA10 siRNA or respective controls. Quantitative real-time RT-PCR was performed to determine expression of HOXA10 and Calpain5 in each group. Transfection of HESC cells with an HOXA10 expression construct led to increased Calpain5 expression, whereas transfection with siRNA resulted in decreased expression. In conclusion, Calpain5 expression is regulated by HOXA10. Calpain5 expression was decreased in endometriosis likely as a result of decreased HOXA10 expression. Decreased apoptosis in endometrial cells may promote the development of endometriosis through a pathway involving HOXA10, Calpain5 and caspase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.