ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2008
The role of the striatum in aversive learning and aversive prediction errors.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03294148 (Mind-body Treatments for Chronic Back Pain), which is not on this map. Cited by 144 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mind-body Treatments for Chronic Back Pain
Who cites it
144 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Economic value in the Brain: A meta-analysis of willingness-to-pay using the Becker-DeGroot-Marschak auction.PloS one · 2023Pooled it
- The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task.Human brain mapping · 2018Pooled it
- Functional reorganisation in chronic pain and neural correlates of pain sensitisation: A coordinate based meta-analysis of 266 cutaneous pain fMRI studies.Neuroscience and biobehavioral reviews · 2016Pooled it
- Oxytocin Facilitates Approach Behavior to Positive Social Stimuli via Decreasing Anterior Insula Activity.The international journal of neuropsychopharmacology · 2018Trial
- Distinct midbrain and habenula pathways are involved in processing aversive events in humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Dissociable cortico-striatal connectivity abnormalities in major depression in response to monetary gains and penalties.Psychological medicine · 2015Trial
- Levodopa administration modulates striatal processing of punishment-associated items in healthy participants.Psychopharmacology · 2015Trial
- Abnormal brain activity during a reward and loss task in opiate-dependent patients receiving methadone maintenance therapy.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Two sides of the same coin: learning via positive and negative reinforcers in the human striatum.Developmental cognitive neuroscience · 2011Trial
- Is all motivation good for learning? Dissociable influences of approach and avoidance motivation in declarative memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Trial
- Competing value signals impair reward-learning via dopaminergic mechanisms and increase exploration.PLoS biology · 2026Article
- Reward and Imitation in Social Conformity.Brain and behavior · 2026Article
- Anxiety symptoms interact with approach motivations in adolescent risk-taking.Development and psychopathology · 2026Article
- Dorsolateral striatal acetylcholine reorganizes neural ensembles to anticipate threat.bioRxiv : the preprint server for biology · 2025Article
- Functional connectivity between the nucleus accumbens and amygdala underlies avoidance learning during adolescence: Implications for developmental psychopathology.Development and psychopathology · 2025Article
- Baseline physical activity moderates brain-behaviour relationships in response to framed health messages.Social cognitive and affective neuroscience · 2025Article
- Effects of described demonstrator ability on brain and behavior when learning from others.NPJ science of learning · 2025Article
- Representation of Anticipated Rewards and Punishments in the Human Brain.Annual review of psychology · 2025Review
- Childhood urbanicity is associated with emotional episodic memory-related striatal function and common variation in NTRK2.BMC medicine · 2024Article
- Subsecond fluctuations in extracellular dopamine encode reward and punishment prediction errors in humans.Science advances · 2023Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroeconomic studies of decision making have emphasized reward learning as critical in the representation of value-driven choice behaviour. However, it is readily apparent that punishment and aversive learning are also significant factors in motivating decisions and actions. In this paper, we review the role of the striatum and amygdala in affective learning and the coding of aversive prediction errors (PEs). We present neuroimaging results showing aversive PE-related signals in the striatum in fear conditioning paradigms with both primary (shock) and secondary (monetary loss) reinforcers. These results and others point to the general role for the striatum in coding PEs across a broad range of learning paradigms and reinforcer types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.