ArticleActa biomaterialia2009
Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin.
Article in Acta biomaterialia, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed.
- Comparative analysis of postoperative mechanical behavior of immature premolars: apexification vs regeneration.Odontology · 2026Article
- Effect of Intracapsular Pressure on Pulp Sensitivity in Teeth Affected by Jaw Cysts: A Clinical Study Combined With Finite Element Analysis.International dental journal · 2026Article
- Recent Advances in Periodontal Regenerative Medicine: A Focus on the Role of Mechanical Stimulation.Biomedicines · 2025Review
- Hierarchically aligned heterogeneous core-sheath hydrogels.Nature communications · 2025Article
- Healing sequelae following tooth extraction and dental implant placement in an aged, ovariectomy model.JBMR plus · 2024Article
- Effect of revascularisation and apexification procedures on biomechanical behaviour of immature maxillary central incisor teeth: a three-dimensional finite element analysis study.Clinical oral investigations · 2021Article
- Article
- Modeling tooth enamel in FEA comparisons of skulls: Comparing common simplifications with biologically realistic models.iScience · 2021Article
- Nanotechnological approach and bio-inspired materials to face degenerative diseases in aging.Aging clinical and experimental research · 2021Review
- Characterization of Phosphorus Species in Human Dentin by Solid-State NMR.Molecules (Basel, Switzerland) · 2020Article
- A New Technique for Research on Wound Healing through Extraction of Mandibular Lower Incisors in Wistar Rats.European journal of dentistry · 2019Article
- A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration.International journal of molecular sciences · 2018Article
- Periodontal ligament entheses and their adaptive role in the context of dentoalveolar joint function.Dental materials : official publication of the Academy of Dental Materials · 2017Review
- Restorative material and loading type influence on the biomechanical behavior of wedge shaped cervical lesions.Clinical oral investigations · 2016Article
- New Insights on the Composition and the Structure of the Acellular Extrinsic Fiber Cementum by Raman Analysis.PloS one · 2016Article
- When 1+1>2: Nanostructured composites for hard tissue engineering applications.Materials science & engineering. C, Materials for biological applications · 2015Review
- Review of research on the mechanical properties of the human tooth.International journal of oral science · 2014Review
- Comparison of hard tissue interrelationships at the cervical region of teeth based on tooth type and gender difference.Journal of forensic dental sciences · 2014Article
- The adaptive nature of the bone-periodontal ligament-cementum complex in a ligature-induced periodontitis rat model.BioMed research international · 2013Article
- Methods for studying tooth root cementum by light microscopy.International journal of oral science · 2012Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This work seeks to establish comparisons of the physical properties of rat and human cementum, root dentin and their interface, including the cementum-dentin junction (CDJ), as a basis for future studies of the entire periodontal complex using rats as animal models. In this study the structure, site-specific chemical composition and mechanical properties of cementum and its interface with root dentin taken from 9- to 12-month-old rats were compared to the physiologically equivalent 40- to 55-year-old human age group using qualitative and quantitative characterization techniques, including histology, atomic force microscopy (AFM), micro-X-ray computed tomography, Raman microspectroscopy and AFM-based nanoindentation. Based on results from this study, cementum taken from the apical third of the respective species can be represented as a woven fabric with radially and circumferentially oriented collagen fibers. In both species the attachment of cementum to root dentin is defined by a stiffness-graded interface (CDJ/cementum-dentin interface). However, it was concluded that cementum and the cementum-dentin interface from a 9- to 12-month-old rat could be more mineralized, resulting in noticeably decreased collagen fiber hydration and significantly higher modulus values under wet conditions for cementum and CDJ (E(rat-cementum)=12.7+/-2.6 GPa; E(rat-CDJ)=11.6+/-3.2 GPa) compared to a 40- to 55-year-old human (E(human-cementum)=3.73+/-1.8 GPa; E(human-CDJ)=1.5+/-0.7 GPa). The resulting data illustrated that the extensions of observations made from animal models to humans should be justified with substantial and equivalent comparison of data across age ranges (life spans) of mammalian species.
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