Evidence map›Paper›PMID 18829061›Full record

ArticleVirology2008

Varying efficiency of long-term replication of papillomaviruses in Saccharomyces cerevisiae.

Adam J Rogers, Malte Loggen, Karen Lee, Peter C Angeletti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Adam J RogersNebraska Center for Virology, 237 Morrison Center, School of Biological Sciences, University of Nebraska-Lincoln, 4240 Fair Street, Lincoln, NE, 68583-0900, USA.
Malte Loggen
Karen Lee
Peter C Angeletti
University of Nebraska–Lincoln · US

Funding

VIRAL SHUTOFF OF HOST TRANSCRIPTION--PBCV-1 INFECTEDP20RR015635 · NCRR · UNIVERSITY OF NEBRASKA LINCOLN · PI ANGELETTI, PETER C. · 2000 to 2009
$22.1M
Maintenance of Human Papillomavirus GenomesK01CA100736 · NCI · UNIVERSITY OF NEBRASKA LINCOLN · PI ANGELETTI, PETER C. · 2003 to 2007
$614k
NCI NIH HHS K01 CA100736NCI NIH HHS K01CA100736NCRR NIH HHS 5P20RR015635NCRR NIH HHS P20 RR015635
6 · The paper itself

Abstract

Human papillomaviruses (HPVs) replicate in mitotically active basal keratinocytes. Two virally encoded proteins, E1, a helicase, and E2, a transcription factor, are important players in replication and maintenance of HPV episomes. We previously showed that HPV16 could replicate stably in Saccharomyces cerevisiae [Angeletti, P.C., Kim, K., Fernandes, F.J., and Lambert, P.F. (2002)] and we identified cis-elements that mediate replication and maintenance [J. Virol. 76(7), 3350-3358.; Kim, K., Angeletti, P.C., Hassebroek, E.C., and Lambert, P.F. (2005)]. Here, we demonstrate that although multiple HPV genomes replicate stably in yeast, they do so with differing long-term efficiency; HPV6-Ura3 is replicated at the highest copy number, followed by HPV31-Ura3 and HPV16-Ura3 respectively, HPV11-Ura3 and HPV18-Ura3 were unable replicate without the presence of E2 expression and BPV-1-Ura3 was unable to replicate, with or without the presence of E2. These studies suggest genotype-specific differences in HPV replication and maintenance.

Indexed as

Virus ReplicationFungal ProteinsPapillomaviridaePlasmidsSaccharomyces cerevisiaeFungal Proteins

Identifiers

PMID18829061
PMCPMC2605936
OpenAlexW1982160907

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.