ArticleReproductive biology and endocrinology : RB&E2008
Role of cervical dendritic cell subsets, co-stimulatory molecules, cytokine secretion profile and beta-estradiol in development of sequalae to Chlamydia trachomatis infection.
Article in Reproductive biology and endocrinology : RB&E, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 31 citations in OpenAlex.
- Chlamydia trachomatis infection and risk of cervical intraepithelial neoplasia.Sexually transmitted infections · 2011Trial
- UnveilingiScience · 2025Article
- Study Models forMicroorganisms · 2025Review
- Ewe breed differences in the cervical transcriptome at the follicular phase of a synchronised oestrous cycle.BMC genomics · 2022Article
- Cytokine profile in Nigerians with tubal infertility.Central-European journal of immunology · 2016Article
- IL-36γ Augments Host Defense and Immune Responses in Human Female Reproductive Tract Epithelial Cells.Frontiers in microbiology · 2016Article
- Animal models for studying female genital tract infection with Chlamydia trachomatis.Infection and immunity · 2013Review
- Consequences of nongenomic actions of estradiol on pathogenic genital tract response.Journal of molecular signaling · 2013Article
- Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.Clinical & developmental immunology · 2011Review
- Female reproductive hormones and biomarkers of oxidative stress in genital Chlamydia infection in tubal factor infertility.Journal of reproduction & infertilityArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChlamydia trachomatis infection of the female genital tract can lead to serious sequelae resulting in fertility related disorders. Little is known about the mechanism leading to Chlamydia induced pathology and factors responsible for it. As only some of the women develops reproductive disorders while majority of the women clears infection without any severe sequalae, mucosal immune response in women with or without fertility disorders was studied to identify factors which may lead to final clinical outcome of chlamydial infection.
methodsMyeloid DCs (mDCs) and plasmacytoid DCs (pDCs) populations in cervical mucosa and peripheral blood were analyzed in controls and Chlamydia positive women with or without fertility disorders with multicoloured flow cytometric analysis. Cervical cytokines (IL-6, IL-8, IL-10, IL-12, TNF-alpha and IFN-gamma), C-reactive protein levels and sex hormone levels in serum were quantified by ELISA.
resultsIn cervix of Chlamydia positive women with fertility disorders, significantly high (P < 0.05) numbers of pDCs were present with increased CD80 expression. pDCs correlated significantly with C-reactive protein levels, IL-6 and IFN-gamma levels in women with fertility disorders. In contrast, mDCs showed significant upregulation of CD1a during chlamydial infection and correlated significantly with IL-12 levels in Chlamydia positive fertile women. beta-estradiol levels were significantly higher in women having fertility disorders as compared to fertile women and have significant correlations (r = 0.65; P < 0.05) with pDCs numbers, CD80 expression, IL-6 levels and IFN-gamma levels in these women.
conclusionThese results suggest that development of sequalae in some women can be a result of interplay of many factors including type of dendritic cell, co stimulatory molecule expression, cytokine secretion pattern and hormone levels.
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