ReviewMalaria journal2008
Heterologous expression of plasmodial proteins for structural studies and functional annotation.
Review in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 79 citations in OpenAlex.
- A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions.PLoS neglected tropical diseases · 2015Trial
- Semaphorin-7A is an erythrocyte receptor for P. falciparum merozoite-specific TRAP homolog, MTRAP.PLoS pathogens · 2012Trial
- Semi-synthesis of the C-terminal region ofRSC chemical biology · 2026Article
- Stabilizing Plasmodium falciparum proteins for small molecule drug discovery.Protein science : a publication of the Protein Society · 2026Article
- Study of dense granule proteins inFrontiers in immunology · 2025Article
- Comparative genomics of two protozoansHeliyon · 2024Article
- Discovery of Novel Binders to Sterol Regulatory Element-Binding Protein-1 by High-Throughput Screening.ACS medicinal chemistry letters · 2024Article
- Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum.NPJ systems biology and applications · 2024Article
- Evaluation of the binding interactions between Plasmodium falciparum Kelch-13 mutant recombinant proteins with artemisinin.PloS one · 2024Article
- Preliminary characterization of Plasmodium vivax sporozoite antigens as pre-erythrocytic vaccine candidates.PLoS neglected tropical diseases · 2023Article
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- Article
- Purification and initial characterization of Plasmodium falciparum KMicrobial cell factories · 2020Article
- A panel of recombinant proteins from human-infective Plasmodium species for serological surveillance.Malaria journal · 2020Article
- Functional Characterization and Comparison ofMolecular & cellular proteomics : MCP · 2020Article
- Heterologous expression inFEBS open bio · 2018Article
- Review
- Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate.Scientific reports · 2017Article
- Recombinant vacuolar iron transporter family homologue PfVIT from human malaria-causing Plasmodium falciparum is a FeScientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malaria remains the world's most devastating tropical infectious disease with as many as 40% of the world population living in risk areas. The widespread resistance of Plasmodium parasites to the cost-effective chloroquine and antifolates has forced the introduction of more costly drug combinations, such as Coartem. In the absence of a vaccine in the foreseeable future, one strategy to address the growing malaria problem is to identify and characterize new and durable antimalarial drug targets, the majority of which are parasite proteins. Biochemical and structure-activity analysis of these proteins is ultimately essential in the characterization of such targets but requires large amounts of functional protein. Even though heterologous protein production has now become a relatively routine endeavour for most proteins of diverse origins, the functional expression of soluble plasmodial proteins is highly problematic and slows the progress of antimalarial drug target discovery. Here the status quo of heterologous production of plasmodial proteins is presented, constraints are highlighted and alternative strategies and hosts for functional expression and annotation of plasmodial proteins are reviewed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.