ArticleAmerican journal of human genetics1991
Isolation of a human DNA sequence which spans the fragile X.
Article in American journal of human genetics, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 47 citations in OpenAlex.
- Precision Sensorimotor Control in Aging FMR1 Gene Premutation Carriers.Frontiers in integrative neuroscience · 2019Article
- RNA biology of disease-associated microsatellite repeat expansions.Acta neuropathologica communications · 2017Review
- Augmented noncanonical BMP type II receptor signaling mediates the synaptic abnormality of fragile X syndrome.Science signaling · 2016Article
- Mouse Genetic Models of Human Brain Disorders.Frontiers in genetics · 2016Review
- Ovarian abnormalities in a mouse model of fragile X primary ovarian insufficiency.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Article
- The gene encoding the fragile X RNA-binding protein is controlled by nuclear respiratory factor 2 and the CREB family of transcription factors.Nucleic acids research · 2006Article
- Direct molecular analysis of the fragile X syndrome in a sample of Egyptian and German patients using non-radioactive PCR and Southern blot followed by chemiluminescent detection.Human genetics · 1995Article
- The fragile X syndrome: isolation of the FMR-1 gene and characterization of the fragile X mutation.Chromosoma · 1992Review
- Development and plasticity of the Drosophila larval neuromuscular junction.Wiley interdisciplinary reviews. Developmental biologyReview
- Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify the sequences involved in the expression of the fragile X and to characterize the molecular basis of the genetic lesion, we have constructed yeast artificial chromosomes (YACs) containing human DNA and have screened them with cloned DNA probes which map close to the fragile site at Xq27.3. We have isolated and partly characterized a YAC containing approximately 270 kb of human DNA from an X chromosome which expresses the fragile X. This sequence in a yeast artificial ring chromosome, XTY26, hybridizes to the two closest DNA markers, VK16 and Do33, which flank the fragile site. The human DNA sequence in XTY26 also spans the fragile site on chromosome in situ hybridization. When a restriction map of XTY26, derived by using infrequently cutting restriction enzymes, is compared with similar YAC maps derived from non-fragile-X patients, no large-scale differences are observed. This YAC, XTY26, may enable (a) the fragile site to be fully characterized at the molecular level and (b) the pathogenetic basis of the fragile-X syndrome to be determined.
Indexed as
Identifiers
1882843PMC1683130W111563181What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.