ReviewImmunologic research2009
How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum.
Review in Immunologic research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Article
- Engineering white blood cell membrane-camouflaged nanocarriers for inflammation-related therapeutics.Bioactive materials · 2023Review
- Centrosome Positioning in MigratingCells · 2022Article
- ELMO2 association with GPeerJ · 2020Article
- Adaptation of Living Systems.Annual review of condensed matter physics · 2018Article
- Database constraints applied to metabolic pathway reconstruction tools.TheScientificWorldJournal · 2014Article
- A novel human receptor involved in bitter tastant detection identified using Dictyostelium discoideum.Journal of cell science · 2013Article
- Phosphorylation of chemoattractant receptors regulates chemotaxis, actin reorganization and signal relay.Journal of cell science · 2013Article
- Cell migration: regulation of cytoskeleton by Rap1 in Dictyostelium discoideum.Journal of microbiology (Seoul, Korea) · 2012Review
- Diverse sensitivity thresholds in dynamic signaling responses by social amoebae.Science signaling · 2012Article
- Signaling network from GPCR to the actin cytoskeleton during chemotaxis.Bioarchitecture · 2012Article
- Chemotaxis in cancer.Nature reviews. Cancer · 2011Review
- The professional phagocyte Dictyostelium discoideum as a model host for bacterial pathogens.Current drug targets · 2011Review
- Nhe1 is essential for potassium but not calcium facilitation of cell motility and the monovalent cation requirement for chemotactic orientation in Dictyostelium discoideum.Eukaryotic cell · 2011Article
- Article
- Autophagy in inflammatory diseases.International journal of cell biology · 2011Article
- Tyrosine phosphorylation-mediated signaling pathways in dictyostelium.Journal of signal transduction · 2011Article
- Article
- Involvement of Src family tyrosine kinase in apoptosis of human neutrophils induced by protozoan parasite Entamoeba histolytica.The Korean journal of parasitology · 2010Article
- Chemotaxis: new role for Ras revealed.Protein & cell · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Human leukocytes, including macrophages and neutrophils, are phagocytic immune cells that capture and engulf pathogens and subsequently destroy them in intracellular vesicles. To accomplish this vital task, these leukocytes utilize two basic cell behaviors-chemotaxis for chasing down infectious pathogens and phagocytosis for destroying them. The molecular mechanisms controlling these behaviors are not well understood for immune cells. Interestingly, a soil amoeba, Dictyostelium discoideum, uses these same behaviors to pursue and injest its bacterial food source and to organize its multi-cellular development. Consequently, studies of this model system have provided and will continue to provide us with mechanistic insights into the chemotaxis and phagocytosis of immune cells. Here, we review recent research in these areas that have been conducted in the Chemotaxis Signal Section of NIAID's Laboratory of Immunogenetics.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.