ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2008
Strain and model dependent differences in inflammatory cell recruitment in mice.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
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- Boosting the peripheral immune response in the skeletal muscles improved motor function in ALS transgenic mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2022Article
- Analgesic Comparison of Flunixin Meglumine or Meloxicam for Soft-Tissue Surgery in Sheep: A Pilot Study.Animals : an open access journal from MDPI · 2021Article
- Tenascin-C Deficiency Is Associated With Reduced Bacterial Outgrowth DuringFrontiers in immunology · 2021Article
- Frontline Science: Rev-Erbα links blue light with enhanced bacterial clearance and improved survival in murine Klebsiella pneumoniae pneumonia.Journal of leukocyte biology · 2020Article
- The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.Frontiers in immunology · 2018Article
- Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation.Nature biotechnology · 2017Article
- Effects of decreased dopamine transporter levels on nigrostriatal neurons and paraquat/maneb toxicity in mice.Neurobiology of aging · 2017Article
- The role of different strain backgrounds in bacterial endotoxin-mediated sensitization to neonatal hypoxic-ischemic brain damage.Neuroscience · 2015Article
- Critical Role of Mast Cells and Peroxisome Proliferator-Activated Receptor γ in the Induction of Myeloid-Derived Suppressor Cells by Marijuana Cannabidiol In Vivo.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.Blood · 2015Article
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- Plasminogen regulates stromal cell-derived factor-1/CXCR4-mediated hematopoietic stem cell mobilization by activation of matrix metalloproteinase-9.Arteriosclerosis, thrombosis, and vascular biology · 2011Article
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- Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function.Journal of medicinal chemistry · 2011Article
- Inter-strain differences of serotonergic inhibitory pain control in inbred mice.Molecular pain · 2010Article
- Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.The Journal of clinical investigation · 2010Article
- A Strong Impact of Genetic Background on Gut Microflora in Mice.International journal of inflammation · 2010Article
- Wide genetic variation in the native pial collateral circulation is a major determinant of variation in severity of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
OBJECTIVE AND
designThe objective of this study was to determine genetic differences in inflammation in these distinct inbred mouse strains.
methodsPeritoneal leukocyte recruitment, matrix metalloproteinases and cytokines were quantified in A/J, 129/svJ, C57BL/6J, using thioglycollate or biomaterial implants as inflammatory stimuli.
resultsIn response to thioglycollate, A/J had significant decreases compared to C57BL/6J in both neutrophil (86 %) and macrophage (62 %) recruitment, and 129/svJ had a significant (43 %) decrease compared to C57BL/6J in macrophage recruitment. The reduced leukocyte recruitment corresponded to reduced matrix metalloproteinase-9. In the bioimplant model, 129/svJ had a 2-fold increase in neutrophil and macrophage recruitment compared to C57BL/6J, and the increased leukocyte recruitment corresponded to elevated cytokines, monocyte inhibitory protein-2 and monocyte chemoattractant protein-1, in the lavage compared to the values for C57BL/6J.
conclusionNot only was leukocyte recruitment strain dependent, but the three strains had marked differences in metalloproteinases and cytokine response. In addition, there were model specific differences in the metalloproteinase and cytokine response to the two inflammatory stimuli. Thus, inflammatory cell recruitment is genetically determined and stimulus specific and may determine the susceptibility to complex diseases.
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