ArticleVascular health and risk management2008
Cigarette smoking leads to reduced relaxant responses of the cutaneous microcirculation.
Article in Vascular health and risk management, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- Trial
- Cigarette Smoking Blunts Exercise-Induced Heart Rate Response among Young Adult Male Smokers.International journal of environmental research and public health · 2019Trial
- Trial
- Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length.Angiogenesis · 2024Article
- Peripheral and Central Smell Regions in Migraine Patients using Maraş Powder (Smokeless Tobacco): A Magnetic Resonance Imaging Evaluation.Journal of neurological surgery. Part B, Skull base · 2022Article
- Remote Photoplethysmography for Evaluation of Cutaneous Sensory Nerve Fiber Function.Sensors (Basel, Switzerland) · 2021Article
- Impaired Microvascular Response to Muscle Stretching in Chronic Smokers With Type 2 Diabetes.Frontiers in bioengineering and biotechnology · 2020Article
- Tobacco Use is a Modifiable Risk Factor for Post-Transplant Biliary Complications.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2017Article
- Article
- Cigarette Smoking and Risk of Incident Rosacea in Women.American journal of epidemiology · 2017Article
- Nitroxide pharmaceutical development for age-related degeneration and disease.Frontiers in genetics · 2015Review
- Determinants of brachial-ankle pulse wave velocity and carotid-femoral pulse wave velocity in healthy Koreans.Journal of Korean medical science · 2014Article
- Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers.American journal of physiology. Heart and circulatory physiology · 2014Article
- Effects of smokeless tobacco (Maras powder) use on carotid intima media thickness.Medical science monitor : international medical journal of experimental and clinical research · 2013Article
- Contrast-enhanced ultrasound evaluation of peripheral microcirculation in diabetic patients: effects of cigarette smoking.La Radiologia medica · 2013Article
- Gender difference in albuminuria and ischemic heart disease in type 2 diabetes.Clinical medicine & research · 2012Article
- Effects of cigarette smoking, metabolic syndrome and dehydroepiandrosterone deficiency on intima-media thickness and endothelial function in hypertensive postmenopausal women.Medical science monitor : international medical journal of experimental and clinical research · 2012Article
- Deteriorated function of cutaneous microcirculation in chronic congestive heart failure.Journal of geriatric cardiology : JGC · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSmoking is a major risk factor for cardiovascular disease. The present study was undertaken to examine if cigarette smoking translates into reduced relaxant responses of the peripheral microcirculation.
methodsThe cutaneous forearm blood flow was measured by laser Doppler flowmetry. The vasodilator response to the iontophorectic administration of acetylcholine (ACh), acting via an endothelial mechanism, and sodium nitroprusside (SNP), and acting via a smooth muscle mechanism were studied. The study population consisted of 17 nonsmokers and 17 current smokers (mean age 64+/-2 years, 13 females and 4 males) in each matched group.
resultsThere was no difference between the groups in baseline characteristics or in basal flow. Smokers showed however significantly reduced responses to both ACh (mean +/- SEM, from 973+/-137% in nonsmokers to 651+/-114% in smokers, p<0.05) and SNP (from 575+/-111% in nonsmokers to 355+/-83% in smokers, p<0.05). The response to the local heating (44 degrees C) was reduced in smokers (from 1188+/-215% in nonsmokers to 714+/-107% in smokers, p<0.01). In addition, there was no difference between men and women within the groups.
conclusionsThe data show that cigarette smoking results in reduced peripheral microvascular responses to both endothelial and smooth muscle cell stimulation in healthy subjects, suggesting a generalized microvascular vasomotor function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.