ArticlePLoS neglected tropical diseases2008
Dermal-type macrophages expressing CD209/DC-SIGN show inherent resistance to dengue virus growth.
Article in PLoS neglected tropical diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 46 citations in OpenAlex.
- Polysaccharide-engineered mitochondria reprogram macrophages to resolve diabetic wound inflammation and promote repair.Bioactive materials · 2026Article
- Expansion of myeloid suppressor cells and suppression of Lassa virus-specific T cells during fatal Lassa fever.PLoS pathogens · 2025Article
- NOD2 Responds to Dengue Virus Type 2 Infection in Macrophage-like Cells Interacting with MAVS Adaptor and Affecting IFN-α Production and Virus Titers.Pathogens (Basel, Switzerland) · 2024Article
- Catestatin in innate immunity and Cateslytin-derived peptides against superbugs.Scientific reports · 2021Article
- The monocyte-macrophage-mast cell axis in dengue pathogenesis.Journal of biomedical science · 2018Review
- Innate immune receptors drive dengue virus immune activation and disease.Future virology · 2017Review
- Antibody-Dependent Enhancement of Dengue Virus Infection in Primary Human Macrophages; Balancing Higher Fusion against Antiviral Responses.Scientific reports · 2016Article
- Soluble mediators produced by the crosstalk between microvascular endothelial cells and dengue-infected primary dermal fibroblasts inhibit dengue virus replication and increase leukocyte transmigration.Immunologic research · 2016Article
- Dermal CD14(+) Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4.The Journal of investigative dermatology · 2015Article
- Association of MRC-1 and IL-28B with the treatment outcome of hepatitis C: a case control study.BMC gastroenterology · 2014Article
- Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.The Journal of experimental medicine · 2014Article
- Smuggling across the border: how arthropod-borne pathogens evade and exploit the host defense system of the skin.The Journal of investigative dermatology · 2014Review
- Relating structure to evolution in class II viral membrane fusion proteins.Current opinion in virology · 2014Review
- Dengue pathogenesis: a disease driven by the host response.Science progress · 2014Review
- Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN.PloS one · 2014Article
- Dendritic cells in dengue virus infection: targets of virus replication and mediators of immunity.Frontiers in immunology · 2014Review
- Comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages.Journal of tropical medicine · 2012Article
- Tumor-associated macrophages in the cutaneous SCC microenvironment are heterogeneously activated.The Journal of investigative dermatology · 2011Article
- Article
- Cells in dengue virus infection in vivo.Advances in virology · 2010Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn important question in dengue pathogenesis is the identity of immune cells involved in the control of dengue virus infection at the site of the mosquito bite. There is evidence that infection of immature myeloid dendritic cells plays a crucial role in dengue pathogenesis and that the interaction of the viral envelope E glycoprotein with CD209/DC-SIGN is a key element for their productive infection. Dermal macrophages express CD209, yet little is known about their role in dengue virus infection. METHODS AND
findingsHere, we showed that dermal macrophages bound recombinant envelope E glycoprotein fused to green fluorescent protein. Because dermal macrophages stain for IL-10 in situ, we generated dermal-type macrophages from monocytes in the presence of IL-10 to study their infection by dengue virus. The macrophages were able to internalize the virus, but progeny virus production was undetectable in the infected cells. In addition, no IFN-alpha was produced in response to the virus. The inability of dengue virus to grow in the macrophages was attributable to accumulation of internalized virus particles into poorly-acidified phagosomes.
conclusionsAborting infection by viral sequestration in early phagosomes would present a novel means to curb infection of enveloped virus and may constitute a prime defense system to prevent dengue virus spread shortly after the bite of the infected mosquito.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.