Evidence map›Paper›PMID 18827815›Full record

ArticleBritish journal of cancer2008

Gene expression profiling of liver metastases from colorectal cancer as potential basis for treatment choice.

M A Pantaleo, A Astolfi, M Nannini, P Paterini, G Piazzi, G Ercolani, G Brandi, G Martinelli, A Pession, A D Pinna and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in British journal of cancer, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. ACancer research communications · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Hepatic metastasis from colorectal cancer.Journal of gastrointestinal oncology · 2019
    Review
  14. Managing Synchronous Liver Metastases in Colorectal Cancer.Indian journal of surgical oncology · 2018
    Article
  15. Article
  16. Article
  17. Carbon dating cancer: defining the chronology of metastatic progression in colorectal cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2017
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

M A PantaleoInstitute of Hematology and Medical Oncology LA Seragnoli, S Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
A Astolfi
M Nannini
P Paterini
G Piazzi
G Ercolani
G Brandi
G Martinelli
A Pession
A D Pinna
G Biasco
University of Bologna · ITPoliclinico S.Orsola-Malpighi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At present no reports on gene expression profiling of liver metastases from colorectal cancer are available. We identified two different signatures using Affymetrix platform: epidermal growth factor receptor pathway was upregulated in metachronous lesions, whereas the pathway mainly related to angiogenesis was in synchronous lesions. Synchronous or metachronous liver metastases could be treated differently on the basis of different molecular pathways.

Indexed as

Gene Expression ProfilingAdultAgedBiomarkers, TumorColorectal NeoplasmsErbB ReceptorsFemaleHumansLiver NeoplasmsMaleMiddle AgedNeoplasms, Multiple PrimaryNeoplasms, Second PrimaryBiomarkers, TumorErbB Receptors

Identifiers

PMID18827815
PMCPMC2584956
OpenAlexW2008374616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.