ReviewKidney international2008
Animal models of sepsis and its complications.
Review in Kidney international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Allosteric modulator potentiates β2AR agonist-promoted bronchoprotection in asthma models.The Journal of clinical investigation · 2023Article
- Fast killing kinetics, significant therapeutic index, and high stability of melittin-derived antimicrobial peptide.Amino acids · 2022Article
- The Anti-Sepsis Effect of Isocorydine Screened from Guizhou Ethnic Medicine is Closely Related to Upregulation of Vitamin D Receptor Expression and Inhibition of NFκB p65 Translocation into the Nucleus.Journal of inflammation research · 2022Article
- Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases.Acta pharmacologica Sinica · 2021Article
- Rivaroxaban improves vascular response in LPS-induced acute inflammation in experimental models.PloS one · 2020Article
- Sepsis and cirrhosis in growing animals: description of a new experimental model and its pathological and immunological reliability.Clinics (Sao Paulo, Brazil) · 2020Article
- Sub-anesthesia Dose of Isoflurane in 60% Oxygen Reduces Inflammatory Responses in Experimental Sepsis Models.Chinese medical journal · 2017Article
- Wnt5A/Ryk signaling critically affects barrier function in human vascular endothelial cells.Cell adhesion & migration · 2017Article
- Differential Paradigms in Animal Models of Sepsis.Current infectious disease reports · 2016Review
- Defining the optimal animal model for translational research using gene set enrichment analysis.EMBO molecular medicine · 2016Article
- Modeling and Hemofiltration Treatment of Acute Inflammation.Processes (Basel, Switzerland) · 2016Article
- Strategies to improve drug development for sepsis.Nature reviews. Drug discovery · 2014Review
- The ethical dimension in published animal research in critical care: the dark side of our moon.Critical care (London, England) · 2014Article
- Animal models of sepsis.Virulence · 2014Review
- Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.Physiological reviews · 2013Article
- Current trends in inflammatory and immunomodulatory mediators in sepsis.Journal of leukocyte biology · 2013Review
- The inflammatory response in sepsis.Trends in immunology · 2013Review
- New approaches to the study of sepsis.EMBO molecular medicine · 2012Review
- Ensemble models of neutrophil trafficking in severe sepsis.PLoS computational biology · 2012Article
- Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia.BMC medical research methodology · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most currently used animal sepsis models fail to adequately replicate the clinical problem and, therefore, have only limited utility for investigating pathophysiological mechanisms or testing the efficacy of new therapeutic agents. Recent experimental findings support this view and suggest that models of acute infection in mice with pre-existing renal dysfunction may be useful in the development pathway for new therapeutic agents for sepsis.
Indexed as
Identifiers
18827799What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.