ReviewJournal of the American Academy of Child and Adolescent Psychiatry2008
Brain imaging in pediatric obsessive-compulsive disorder.
Review in Journal of the American Academy of Child and Adolescent Psychiatry, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Neuroimaging of cognitive brain function in paediatric obsessive compulsive disorder: a review of literature and preliminary meta-analysis.Journal of neural transmission (Vienna, Austria : 1996) · 2012Pooled it
- Glutamate in Pediatric Obsessive-Compulsive Disorder and Response to Cognitive-Behavioral Therapy: Randomized Clinical Trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Trial
- 12-week, placebo-controlled trial of add-on riluzole in the treatment of childhood-onset obsessive-compulsive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Gray matter volumes in obsessive-compulsive disorder before and after fluoxetine or cognitive-behavior therapy: a randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Association of Brain Structural Measurements and Polygenic Risk Scores with Obsessive-Compulsive Symptoms in Adolescents Diagnosed with Obsessive-Compulsive Disorder, Attention-Deficit/Hyperactivity Disorder, Anxiety, Depression, Autism and Tic Disorders.medRxiv : the preprint server for health sciences · 2025Article
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- Early Identification and Intervention in Pediatric Obsessive-Compulsive Disorder.Brain sciences · 2023Review
- Sustained attention induces altered effective connectivity of the ascending thalamo-cortical relay in obsessive-compulsive disorder.Frontiers in psychiatry · 2022Article
- Gray Matter Alterations in Pediatric Schizophrenia and Obsessive-Compulsive Disorder: A Systematic Review and Meta-Analysis of Voxel-Based Morphometry Studies.Frontiers in psychiatry · 2022Article
- Developmental Considerations in Obsessive Compulsive Disorder: Comparing Pediatric and Adult-Onset Cases.Frontiers in psychiatry · 2021Review
- Obsessive-compulsive disorder in children and adolescents: epidemiology, diagnosis and management.Translational pediatrics · 2020Review
- Neuroanatomical Changes Underlying Vertical HIV Infection in Adolescents.Frontiers in immunology · 2019Article
- Rodent models of obsessive compulsive disorder: Evaluating validity to interpret emerging neurobiology.Neuroscience · 2017Review
- Cingulate and thalamic metabolites in obsessive-compulsive disorder.Psychiatry research. Neuroimaging · 2016Article
- A Voxel Based Morphometry Study of Brain Gray Matter Volumes in Juvenile Obsessive Compulsive Disorder.Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2015Article
- A selective review of glutamate pharmacological therapy in obsessive-compulsive and related disorders.Psychology research and behavior management · 2015Review
- Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder.Biology of mood & anxiety disorders · 2014Article
- Effects of intensive cognitive-behavioral therapy on cingulate neurochemistry in obsessive-compulsive disorder.Journal of psychiatric research · 2013Article
- Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study.Psychiatry research · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo review progress in understanding pediatric obsessive-compulsive disorder (OCD). The focus is on the frontal-striatal-thalamic model of OCD, neurobiological and genetic studies of the disorder, and their influence on recent advances in treatment.
methodComputerized literature searches were conducted with the key words "obsessive-compulsive disorder" in conjunction with "pediatric," "genetics," and "imaging."
resultsNeuroimaging studies find evidence to support the frontal-striatal-thalamic model. Genetic and neurochemical studies also implicate glutamate in the pathological finding of OCD. This has led to the application of glutamate-modulating agents to treat OCD.
conclusionsStudies of pediatric OCD have led to a refined frontal-striatal-thalamic model of pathogenesis and are having an evidence-based impact on treatment. Despite this progress, fully explanatory models are still needed that would allow for accurate prognosis and the development of targeted and efficacious treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.