ArticleAudiology & neuro-otology2009
Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.
Article in Audiology & neuro-otology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- The Blood-Labyrinth Barrier: Non-Invasive Delivery Strategies for Inner Ear Drug Delivery.Pharmaceutics · 2025Review
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- Plural molecular and cellular mechanisms of pore domainbioRxiv : the preprint server for biology · 2024Article
- β-Catenin transcriptional activity is required for establishment of inner pillar cell identity during cochlear development.PLoS genetics · 2023Article
- Repressor element 1-silencing transcription factor deficiency yields profound hearing loss through KeLife · 2022Article
- Low-voltage Activating KExperimental neurobiology · 2022Article
- TwoFrontiers in physiology · 2020Article
- Maturation of NaV and KV Channel Topographies in the Auditory Nerve Spike Initiator before and after Developmental Onset of Hearing Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Potassium channel activator attenuates salicylate-induced cochlear hearing loss potentially ameliorating tinnitus.Frontiers in neurology · 2015Article
- Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.Journal of cellular and molecular medicine · 2013Article
- Article
- Kv7-type channel currents in spiral ganglion neurons: involvement in sensorineural hearing loss.The Journal of biological chemistry · 2010Article
- Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension.British journal of pharmacology · 2009Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
KCNQ1 and KCNQ4 voltage-gated potassium channel subunits play key roles in hearing. Other members of the KCNQ family also encode slow, low voltage-activated K(+) M currents. We have previously reported the presence of M-like K(+) currents in sensory hair cells, and expression of Kcnq family genes in the cochlea. Here, we describe Kcnq2/3 gene expression and distribution of M channel subunits KCNQ2 and 3 in the cochlea. By using RT-PCR, we found expression of Kcnq2 in the modiolus and organ of Corti, while Kcnq3 expression was also detected in the cochlear lateral wall. Five alternative splice variants of the Kcnq2 gene, one of which has not been reported previously, were identified in the rat cochlea. KCNQ2 and KCNQ3 immunoreactivities were observed in spiral ganglion auditory neurons. In addition, the unmyelinated parts of the nerve fibers innervating hair cells and synaptic regions under hair cells showed KCNQ2 immunoreactivity. KCNQ3 immunoreactivity was also prominent in spiral ganglion satellite cells. These findings suggest that cochlear M channels play important roles in regulation of cellular excitability and maintenance of cochlear K(+) homeostasis in the auditory system.
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