ArticlePhysiological genomics2008
Network analysis of temporal effects of intermittent and sustained hypoxia on rat lungs.
Article in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Deciphering regulatory patterns in a mouse model of hyperoxia-induced acute lung injury.PeerJ · 2024Article
- Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype.Sleep · 2022Article
- Intermittent Hypoxemia and Bronchopulmonary Dysplasia: Manifestations of Immature Respiratory Control and the Preterm Lung.American journal of respiratory and critical care medicine · 2021Article
- Obstructive Sleep Apnea, Hypoxia, and Nonalcoholic Fatty Liver Disease.American journal of respiratory and critical care medicine · 2019Review
- Decreased expression of hepatic cytochrome P450 1A2 (CYP1A2) in a chronic intermittent hypoxia mouse model.Journal of thoracic disease · 2018Article
- A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.PloS one · 2018Article
- Article
- Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease.Global cardiology science & practice · 2016Review
- Integration of complex data sources to provide biologic insight into pulmonary vascular disease (2015 Grover Conference Series).Pulmonary circulation · 2016Review
- Microarray analysis in pulmonary hypertension.The European respiratory journal · 2016Review
- Effect of hypoxia on lung gene expression and proteomic profile: insights into the pulmonary surfactant response.Journal of proteomics · 2014Article
- Genomic differences distinguish the myofibroblast phenotype of distal lung fibroblasts from airway fibroblasts.American journal of respiratory cell and molecular biology · 2011Article
- Review
- Upregulation of transcription factor NRF2-mediated oxidative stress response pathway in rat brain under short-term chronic hypobaric hypoxia.Functional & integrative genomics · 2011Article
- Chronic intermittent hypoxia induces lung growth in adult mice.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Histaminergic responses by hypothalamic neurons that regulate lordosis and their modulation by estradiol.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Genomewide RNA expression profiling in lung identifies distinct signatures in idiopathic pulmonary arterial hypertension and secondary pulmonary hypertension.American journal of physiology. Heart and circulatory physiology · 2010Article
- Heart rhythm genomic fabric in hypoxia.Biochemical and biophysical research communications · 2010Article
- Distinct mechanisms underlying tolerance to intermittent and constant hypoxia in Drosophila melanogaster.PloS one · 2009Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
unlabelledThe molecular networks underlying the lung response to hypoxia are not fully understood. We employed systems biology approaches to study temporal effects of intermittent or sustained hypoxia on gene expression in rat lungs. We obtained gene expression profiles from rats exposed to intermittent or sustained hypoxia lasting 0-30 days and identified differentially expressed genes, their patterns, biological processes, and regulatory networks critical for lung response to intermittent or sustained hypoxia. We validated selected genes with quantitative real-time PCR. Intermittent and sustained hypoxia induced two distinct sets of genes in rat lungs that displayed different temporal expression patterns. Intermittent hypoxia induced genes mostly involved in ion transport and homeostasis, neurological processes, and steroid hormone receptor activity, while sustained hypoxia induced genes principally participating in immune responses. The intermittent hypoxia-activated network suggested a role for cross talk between estrogen receptor 1 (ESR1) and other key proteins in hypoxic responses. The sustained hypoxia-activated network was indicative of vascular remodeling and pulmonary hypertension. We confirmed the temporal expression changes of 12 genes (including the Esr1 gene and 4 ESR1 target genes) in intermittent hypoxia and 8 genes in sustained hypoxia with quantitative real-time PCR.
conclusionsintermittent and sustained hypoxia induced distinct gene expression patterns in rat lungs. The functional characteristics of genes activated by these two distinct perturbations suggest their roles in the downstream physiological effects of intermittent and sustained hypoxia. Our results demonstrate the discovery potential of applying systems biology approaches to the understanding of mechanisms underlying hypoxic lung response.
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