Evidence map›Paper›PMID 18826821›Full record

ArticleEmerging infectious diseases2008

Cryptosporidium species and subtypes and clinical manifestations in children, Peru.

Vitaliano A Cama, Caryn Bern, Jacqueline Roberts, Lilia Cabrera, Charles R Sterling, Ynes Ortega, Robert H Gilman, Lihua Xiao

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 4 pooled it
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 4 syntheses or guidelines pooled it, 291 citations in OpenAlex.

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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Vitaliano A CamaCenters for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Caryn Bern
Jacqueline Roberts
Lilia Cabrera
Charles R Sterling
Ynes Ortega
Robert H Gilman
Lihua Xiao
Centers for Disease Control and Prevention · USJohns Hopkins University · USPrisma · PEUniversity of Georgia · US

Funding

Vaccine development for porcine cysticercosis: oncosphere antigensU01AI035894 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 1994 to 2004
$3.7M
Serological &Molecular Techniques-- Epidemiology of Cyclospora cayetanensisP01AI051976 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI GARCIA, HECTOR HUGO · 2002 to 2006
$3.3M
Transmission Dynamics of Cryptosporidium spR21AI059661 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2004 to 2005
$348k
NIAID NIH HHS 5P01AI051976NIAID NIH HHS 5R21 AI059661NIAID NIH HHS P01 AI051976NIAID NIH HHS R21 AI059661NIAID NIH HHS U01 AI035894NIAID NIH HHS U01-AI35894
6 · The paper itself

Abstract

To determine whether clinical manifestations are associated with genotypes or subtypes of Cryptosporidium spp., we studied a 4-year longitudinal birth cohort of 533 children in Peru. A total of 156 infection episodes were found in 109 children. Data from first infections showed that C. hominis was associated with diarrhea, nausea, vomiting, general malaise, and increased oocyst shedding intensity and duration. In contrast, C. parvum, C. meleagridis, C. canis, and C. felis were associated with diarrhea only. C. hominis subtype families were identified (Ia, Ib, Id, and Ie); all were associated with diarrhea. Ib was also associated with nausea, vomiting, and general malaise. All C. parvum specimens belonged to subtype family IIc. Analysis of risk factors did not show associations with specific Cryptosporidium spp. genotypes or subtypes. These findings strongly suggest that Cryptosporidium spp. and subtypes are linked to different clinical manifestations in children.

Indexed as

AnimalsChild, PreschoolCohort StudiesCryptosporidiosisCryptosporidiumCryptosporidium parvumFecesFemaleGenotypeHumansInfantLongitudinal StudiesMalePeruRisk Factors

Identifiers

PMID18826821
PMCPMC2609889
OpenAlexW2140370872

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.