ArticleBMC genetics2008
Linkage disequilibrium compared between five populations of domestic sheep.
Article in BMC genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Design and Application of a Genome-Wide SNP Array to Improve Conservation Outcomes in the Critically Endangered Southern Corroboree Frog.Molecular ecology resources · 2026Article
- Improved Litter Size in Thin-Tailed Indonesian Sheep Through Analysis of TGIF1 Gene Polymorphisms.Veterinary medicine international · 2025Article
- Linkage Disequilibrium Decay in Selected Cattle Breeds.Animals : an open access journal from MDPI · 2024Article
- Detection of selective sweep in European wild sheep breeds.3 Biotech · 2024Article
- RNA-Seq based selection signature analysis for identifying genomic footprints associated with the fat-tail phenotype in sheep.Frontiers in veterinary science · 2024Article
- The genomic structure of isolation across breed, country and strain for important South African and Australian sheep populations.BMC genomics · 2022Article
- Genome-wide association studies detects candidate genes for wool traits by re-sequencing in Chinese fine-wool sheep.BMC genomics · 2021Article
- Optimum mating designs for exploiting dominance in genomic selection schemes for aquaculture species.Genetics, selection, evolution : GSE · 2021Article
- Linkage Disequilibrium and Effective Population Size of Buffalo Populations of Iran, Turkey, Pakistan, and Egypt Using a Medium Density SNP Array.Frontiers in genetics · 2021Article
- Characterizing Genetic Regulatory Elements in Ovine Tissues.Frontiers in genetics · 2021Article
- Genetic diversity and genetic origin of Lanping black-boned sheep investigated by genome-wide single-nucleotide polymorphisms (SNPs).Archives animal breeding · 2020Article
- Linkage Disequilibrium, Effective Population Size and Genomic Inbreeding Rates in American Mink Using Genotyping-by-Sequencing Data.Frontiers in genetics · 2020Article
- An evaluation of sequencing coverage and genotyping strategies to assess neutral and adaptive diversity.Molecular ecology resources · 2019Article
- Genome-Wide Linkage Disequilibrium and the Extent of Effective Population Sizes in Six Chinese Goat Populations Using a 50K Single Nucleotide Polymorphism Panel.Animals : an open access journal from MDPI · 2019Article
- Analysis of genome-wide DNA arrays reveals the genomic population structure and diversity in autochthonous Greek goat breeds.PloS one · 2019Article
- Genome-wide analyses of the Jeju, Thoroughbred, and Jeju crossbred horse populations using the high density SNP array.Genes & genomics · 2018Article
- RAD Sequencing and a Hybrid Antarctic Fur Seal Genome Assembly Reveal Rapidly Decaying Linkage Disequilibrium, Global Population Structure and Evidence for Inbreeding.G3 (Bethesda, Md.) · 2018Article
- Linkage disequilibrium in Brazilian Santa Inês breed, Ovis aries.Scientific reports · 2018Article
- Genomic diversity and population structure of three autochthonous Greek sheep breeds assessed with genome-wide DNA arrays.Molecular genetics and genomics : MGG · 2018Article
- Potential of Genome-Wide Studies in Unrelated Plus Trees of a Coniferous Species,Frontiers in plant science · 2018Article
Corrections and comments
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3 authors.
Funding
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Abstract
backgroundThe success of genome-wide scans depends on the strength and magnitude of linkage disequilibrium (LD) present within the populations under investigation. High density SNP arrays are currently in development for the sheep genome, however little is known about the behaviour of LD in this livestock species. This study examined the behaviour of LD within five sheep populations using two LD metrics, D' and x2'. Four economically important Australian sheep flocks, three pure breeds (White Faced Suffolk, Poll Dorset, Merino) and a crossbred population (Merino x Border Leicester), along with an inbred Australian Merino museum flock were analysed.
resultsShort range LD (0 - 5 cM) was observed in all five populations, however the persistence with increasing distance and magnitude of LD varied considerably between populations. Average LD (x2') for markers spaced up to 20 cM exceeded the non-syntenic average within the White Faced Suffolk, Poll Dorset and Macarthur Merino. LD decayed faster within the Merino and Merino x Border Leicester, with LD below or consistent with observed background levels. Using marker-marker LD as a guide to the behaviour of marker-QTL LD, estimates of minimum marker spacing were made. For a 95% probability of detecting QTL, a microsatellite marker would be required every 0.1 - 2.5 centimorgans, depending on the population used.
conclusionSheep populations were selected which were inbred (Macarthur Merino), highly heterogeneous (Merino) or intermediate between these two extremes. This facilitated analysis and comparison of LD (x2') between populations. The strength and magnitude of LD was found to differ markedly between breeds and aligned closely with both observed levels of genetic diversity and expectations based on breed history. This confirmed that breed specific information is likely to be important for genome wide selection and during the design of successful genome scans where tens of thousands of markers will be required.
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