ArticleJournal of medical case reports2008
Diagnostic difficulties of Lactobacillus casei bacteraemia in immunocompetent patients: a case report.
Article in Journal of medical case reports, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Microbiome-Targeted Probiotic Strategies for the Prevention and Treatment of Osteomyelitis: A Novel Biological Approach.Probiotics and antimicrobial proteins · 2026Review
- Burrata and the Bean: A Rare Case ofCase reports in infectious diseases · 2026Article
- Both, Limited and Often Fatal Systemic Infections Caused byMicroorganisms · 2025Article
- Antibiotic Resistance Gene Expression in Veterinary Probiotics: Two Sides of the Coin.Veterinary sciences · 2025Review
- Probiotics and Prebiotics for the Treatment of Irritable Bowel Syndrome-A Narrative Review.Journal of clinical medicine · 2024Review
- Evolution of homologous recombination rates across bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Early application of metagenomics next-generation sequencing may significantly reduce unnecessary consumption of antibiotics in patients with fever of unknown origin.BMC infectious diseases · 2023Article
- A Case of Lactobacillus casei Endocarditis Associated With Probiotic Intake in an Immunocompromised Patient.Cureus · 2023Article
- Article
- Association of plasma microbial composition with a leaky gut in obesity-related osteoarthritis: An exploratory study.Osteoarthritis and cartilage open · 2022Article
- Medical treatment of pouchitis: a guide for the clinician.Therapeutic advances in gastroenterology · 2021Review
- Article
- Probiotic Lactobacilli Precautions.Frontiers in microbiology · 2019Article
- Probiotic Survey in Cancer Patients Treated in the Outpatient Department in a Comprehensive Cancer Center.Integrative cancer therapies · 2017Article
- Article
- Mechanisms and therapeutic effectiveness of lactobacilli.Journal of clinical pathology · 2016Review
- Importance of Molecular Methods to Determine Whether a Probiotic is the Source of Lactobacillus Bacteremia.Probiotics and antimicrobial proteins · 2016Article
- Risk and safety of probiotics.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Molecular analysis and clinical significance of Lactobacillus spp. recovered from clinical specimens presumptively associated with disease.Journal of clinical microbiology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLactobacilli are currently proposed as probiotic agents in several dietary products. In blood cultures, they are usually considered as contaminants, but in recent years they have been recognized as causal infectious agents of endocarditis, urinary tract infections, meningitis, intra-abdominal infections and bacteraemia. CASE PRESENTATION: We report a case of Lactobacillus casei bacteraemia in a 66-year-old immunocompetent man with a history of fever of unknown origin. Leuconostoc bacteraemia was demonstrated by blood culture, but a later polymerase chain reaction analysis with sequencing of 16S ribosomal RNA identified Lactobacillus casei and a successful antibiotic therapy was performed.
conclusionBacteraemia caused by probiotic organisms is rare but underestimated, since they are normally regarded as contaminants and their role as primary invaders is not always easily established. Although the consumption of probiotic products cannot be considered a risk factor in the development of diseases caused by usually non-pathogenic bacteria, specific individual clinical histories should be taken into account. This report should alert both clinicians and microbiologists to the possibility of unusual pathogens causing serious illnesses and to the use of 16S ribosomal RNA sequencing for molecular identification as a powerful tool in confirming the diagnosis of infrequent pathogens.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.