ArticleBMC complementary and alternative medicine2008
Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model.
Article in BMC complementary and alternative medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 123 citations in OpenAlex.
- Plant Essential Oils and Chronic Inflammatory Diseases: A Panoramic View of Molecular Mechanisms.Drug design, development and therapy · 2026Review
- Gosha-Jinki-Gan Reduces Inflammation in Chronic Ischemic Stroke Mouse Models by Suppressing the Infiltration of Macrophages.Biomolecules · 2025Article
- Unlocking the medicinal arsenal ofHealth science reports · 2024Article
- Isolation of Anti-Prion Compounds fromMolecules (Basel, Switzerland) · 2024Article
- Review
- Antioxidation Abilities of Sesquiterpenoids fromCombinatorial chemistry & high throughput screening · 2023Article
- Traditional Chinese medicine in treating ischemic stroke by modulating mitochondria: A comprehensive overview of experimental studies.Frontiers in pharmacology · 2023Review
- Pharmacological Profile, Bioactivities, and Safety of Turmeric Oil.Molecules (Basel, Switzerland) · 2022Review
- Analysis of Volatile Constituents inPlants (Basel, Switzerland) · 2022Article
- Comparative Analysis of Volatile Constituents in Root Tuber and Rhizome ofMolecules (Basel, Switzerland) · 2022Article
- Impacts of Commonly Used Edible Plants on the Modulation of Platelet Function.International journal of molecular sciences · 2022Review
- A Comprehensive Review on the Therapeutic Potential ofFrontiers in pharmacology · 2022Review
- Total Synthesis of (±)-Phaeocaulisin D.Synlett : accounts and rapid communications in synthetic organic chemistry · 2021Article
- The Effects of Various Essential Oils on Epilepsy and Acute Seizure: A Systematic Review.Evidence-based complementary and alternative medicine : eCAM · 2019Review
- Review
- Article
- Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.Scientific reports · 2017Article
- Neuroprotective effects of curdione against focal cerebral ischemia reperfusion injury in rats.Neuropsychiatric disease and treatment · 2017Article
- Pre-treatment with a Xingnaojing preparation ameliorates sevoflurane-induced neuroapoptosis in the infant rat striatum.Molecular medicine reports · 2015Article
- Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val.EXCLI journal · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAmong the naturally occurring compounds, turmeric from the dried rhizome of the plant Curcuma longa has long been used extensively as a condiment and a household remedy all over Southeast Asia. Turmeric contains essential oil, yellow pigments (curcuminoids), starch and oleoresin. The present study was designed for investigating the neuroprotective efficacy and the time window for effective therapeutic use of Curcuma oil (C. oil).
methodIn the present study, the effect of post ischemic treatment of C.oil after ischemia induced by occlusion of the middle cerebral artery in the rat was observed. C.oil (500 mg/kg body wt) was given 4 hrs post ischemia. The significant effect on lesion size as visualized by using diffusion-weighted magnetic resonance imaging and neuroscore was still evident when treatment was started 4 hours after insult. Animals were assessed for behavioral deficit scores after 5 and 24 hours of ischemia. Subsequently, the rats were sacrificed for evaluation of infarct and edema volumes and other parameters.
resultsC.oil ameliorated the ischemia induced neurological functional deficits and the infarct and edema volumes measured after 5 and 24 hrs of ischemia. After 24 hrs, immunohistochemical and Western blot analysis demonstrated that the expression of iNOS, cytochrome c and Bax/Bcl-2 were altered after the insult, and antagonized by treatment with C.oil. C.oil significantly reduced nitrosative stress, tended to correct the decreased mitochondrial membrane potential, and also affected caspase-3 activation finally apoptosis.
conclusionHere we demonstrated that iNOS-derived NO produced during ischemic injury was crucial for the up-regulation of ischemic injury targets. C.oil down-regulates these targets this coincided with an increased survival rate of neurons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.