ArticleMolecular microbiology2008
Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor.
Article in Molecular microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- RpoS and the bacterial general stress response.Microbiology and molecular biology reviews : MMBR · 2024Review
- Residual Helicity at the Active Site of the Histidine Phosphocarrier, HPr, Modulates Binding Affinity to Its Natural Partners.International journal of molecular sciences · 2021Article
- Chemical-genetic interrogation of RNA polymerase mutants reveals structure-function relationships and physiological tradeoffs.Molecular cell · 2021Article
- Coordinated Regulation of Rsd and RMF for Simultaneous Hibernation of Transcription Apparatus and Translation Machinery in Stationary-PhaseFrontiers in genetics · 2019Review
- Linking glucose metabolism to the stringent response through the PTS.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Local and global regulation of transcription initiation in bacteria.Nature reviews. Microbiology · 2016Review
- Multipart Chaperone-Effector Recognition in the Type III Secretion System of Chlamydia trachomatis.The Journal of biological chemistry · 2015Article
- Bacterial Sigma Factors and Anti-Sigma Factors: Structure, Function and Distribution.Biomolecules · 2015Review
- Key features of σS required for specific recognition by Crl, a transcription factor promoting assembly of RNA polymerase holoenzyme.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Evidence for sigma factor competition in the regulation of alginate production by Pseudomonas aeruginosa.PloS one · 2013Article
- The E. coli anti-sigma factor Rsd: studies on the specificity and regulation of its expression.PloS one · 2011Article
- In vivo transcription dynamics of the galactose operon: a study on the promoter transition from P1 to P2 at onset of stationary phase.PloS one · 2011Article
- The RpoS-mediated general stress response in Escherichia coli.Annual review of microbiology · 2011Review
- Crl binds to domain 2 of σ(S) and confers a competitive advantage on a natural rpoS mutant of Salmonella enterica serovar Typhi.Journal of bacteriology · 2010Article
- Essential biological processes of an emerging pathogen: DNA replication, transcription, and cell division in Acinetobacter spp.Microbiology and molecular biology reviews : MMBR · 2010Review
- Direct activator/co-activator interaction is essential for bacteriophage T4 middle gene expression.Molecular microbiology · 2009Article
- Small molecule control of virulence gene expression in Francisella tularensis.PLoS pathogens · 2009Article
- A regulator from Chlamydia trachomatis modulates the activity of RNA polymerase through direct interaction with the beta subunit and the primary sigma subunit.Genes & development · 2009Article
- 6S RNA binding to Esigma(70) requires a positively charged surface of sigma(70) region 4.2.Molecular microbiology · 2009Article
- The bacteriophage T4 AsiA protein contacts the beta-flap domain of RNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Bacterial anti-sigma factors typically regulate sigma factor function by restricting the access of their cognate sigma factors to the RNA polymerase (RNAP) core enzyme. The Escherichia coli Rsd protein forms a complex with the primary sigma factor, sigma(70), inhibits sigma(70)-dependent transcription in vitro, and has been proposed to function as a sigma(70)-specific anti-sigma factor, thereby facilitating the utilization of alternative sigma factors. In prior work, Rsd has been shown to interact with conserved region 4 of sigma(70), but it is not known whether this interaction suffices to account for the regulatory functions of Rsd. Here we show that Rsd and the Rsd orthologue AlgQ, a global regulator of gene expression in Pseudomonas aeruginosa, interact with conserved region 2 of sigma(70). We show further that Rsd and AlgQ can interact simultaneously with regions 2 and 4 of sigma(70). Our findings establish that the abilities of Rsd and AlgQ to interact with sigma(70) region 2 are important determinants of their in vitro and in vivo activities.
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