Trial reportInflammatory bowel diseases2008
Enhanced CBir1-specific innate and adaptive immune responses in Crohn's disease.
Trial report in Inflammatory bowel diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- Human gut flagellome profiling using FlaPro reveals TLR5-related phenotype-specific alterations in IBD.Gut microbes · 2026Article
- Crohn's Patients and Healthy Infants Share Immunodominant B Cell Response to Commensal Flagellin Peptide Epitopes.Gastroenterology · 2024Article
- Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TNature medicine · 2023Article
- Epicutaneous Immunotherapy with CBir1 Alleviates Intestinal Inflammation.Inflammatory bowel diseases · 2023Article
- Porphyromonas gingivalis exacerbates ulcerative colitis via Porphyromonas gingivalis peptidylarginine deiminase.International journal of oral science · 2021Article
- Human Microbiota Flagellins Drive Adaptive Immune Responses in Crohn's Disease.Gastroenterology · 2021Article
- Flagellin-Specific CD4 Cytokine Production in Crohn Disease and Controls Is Limited to a Small Subset of Antigen-Induced CD40LJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Microbial modulation of intestinal T helper cell responses and implications for disease and therapy.Mucosal immunology · 2020Review
- The Intermucosal Connection between the Mouth and Gut in Commensal Pathobiont-Driven Colitis.Cell · 2020Article
- Escherichiacoli-Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn's Disease.Cellular and molecular gastroenterology and hepatology · 2020Observational
- Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases.Nature communications · 2019Article
- Expanded TCRβ CDR3 clonotypes distinguish Crohn's disease and ulcerative colitis patients.Mucosal immunology · 2018Article
- IL-10 downregulates CXCR3 expression on Th1 cells and interferes with their migration to intestinal inflammatory sites.Mucosal immunology · 2016Article
- Targeting Antigens to Dec-205 on Dendritic Cells Induces Immune Protection in Experimental Colitis in Mice.European journal of microbiology & immunology · 2016Article
- Clinical Utility of Biomarkers in IBD.Current gastroenterology reports · 2015Review
- Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk.Journal of innate immunity · 2015Article
- Microbiota activation and regulation of innate and adaptive immunity.Immunological reviews · 2014Review
- New perspective on dextran sodium sulfate colitis: antigen-specific T cell development during intestinal inflammation.PloS one · 2013Article
- Article
- Immunoregulation by the gut microbiota.Cellular and molecular life sciences : CMLS · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCBir1 is a dominant antigen with a role in innate and adaptive immunity in mouse models of colitis and antibodies to CBir1 are associated with severe human Crohn's disease (CD). Our aim was to determine whether CBir1 stimulates innate and antigen-specific T-cell responses in CD. We demonstrate that CBir1 enhanced IL-6 and IL-1beta production by peripheral blood (PB) monocytes.
methodsReal time polymerase chain reaction (PCR) was used for measurement of IL6 and IL1 expression. [(3)H] thymidine was used to measure T cell proliferation and Elispot assay was used to measure IFNgamma production.
resultsIL-6 was significantly increased in monocytes from CD compared to controls and ulcerative colitis (UC). Anti-CBir1(+) patients and IL-6 was inversely correlated. A significant increase in CBir1-specific peripheral T-cell proliferation was more evident in cells from CD than controls and UC. CBir1 induced increased numbers of IFN-gamma(+) cells in lamina propria mononuclear cells (LPMC) from CD compared to UC and controls.
conclusionsCBir1 induces enhanced peripheral innate and peripheral and mucosal antigen-specific T-cell responses in CD. Consistent with results from the mouse, CBir1 immune activation could play a role in CD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.