ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2008
Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure.
Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00518440 (A Multi-Center Trial to Study Acute Liver Failure in Adults), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multi-Center Trial to Study Acute Liver Failure in Adults
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- ACG Clinical Guideline: Liver Disease and Pregnancy.The American journal of gastroenterology · 2016Guideline
- Herpes Simplex Virus Hepatitis: An Overlooked Cause of Acute Liver Failure Across a Broad Spectrum of Immunocompromise.Liver international : official journal of the International Association for the Study of the Liver · 2026Review
- Phylogenetic and Genomic Characterization of Whole Genome Sequences of a Herpes Simplex Virus Type 1 Isolate Identified Genomic Variant Characteristics in a Human Subject with Fulminant Hepatitis.International journal of molecular sciences · 2026Article
- Prolonged acyclovir therapy for Herpes simplex virus (HSV)-1-associated hepatitis in an immunocompetent man.IDCases · 2025Article
- Fatal Liver Failure After Herpes-Simplex-Virus-2-Induced Acute Necrotizing Hepatitis: A Case Report.Case reports in hepatology · 2025Article
- Article
- Viral etiologies of acute liver failure.World journal of virology · 2024Review
- Rapid diagnosis of herpes simplex virus 1 and 2 bloodstream infections utilizing a sample-to-answer platform.Journal of clinical microbiology · 2024Article
- Acute liver failure in pregnancy.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Rapid and accurate detection of herpes simplex virus type 2 using a low-cost electrochemical biosensor.Cell reports. Physical science · 2023Article
- Acute liver failure due to herpes simplex viral hepatitis diagnosed by skin lesions and blood tests: a case report.Journal of medical case reports · 2023Article
- A case report of severe systemic herpes simplex virus-1 (HSV-1) infection with multi-organ involvement after a course of oral corticosteroid treatment.BMC infectious diseases · 2022Article
- Acute liver failure due to herpes simplex virus: diagnostic clues and potential role of plasmapheresis: A case report.Medicine · 2021Article
- A Surprising Cause of Liver Abscesses in a Post-Chemotherapy Patient: Herpes Simplex Virus.Cureus · 2021Article
- Acute Liver Failure (ALF) in Pregnancy: How Much Is Pregnancy Related?Hepatology (Baltimore, Md.) · 2020Article
- Herpes Simplex Virus Type 1 Hepatitis in an Immunocompetent Female After Laparoscopic Cholecystectomy.Cureus · 2020Article
- Viral Hepatitis Other than A, B, and C: Evaluation and Management.Clinics in liver disease · 2020Review
- Intensive Care Management of Acute Liver Failure: Considerations While Awaiting Liver Transplantation.Journal of clinical and translational hepatology · 2019Review
- Acute liver failure.Lancet (London, England) · 2019Review
- Odd cause for acute anicteric hepatitis in a woman with systemic lupus erythematosus.BMJ case reports · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Disseminated herpes simplex virus (HSV) infection may lead to acute liver failure (ALF) and the need for emergency liver transplantation (LT). The primary aim of this study was to determine the utility of HSV serological testing and HSV DNA testing by polymerase chain reaction (PCR) in the diagnosis and management of indeterminate, pregnancy-related, and known HSV-related ALF. Stored sera obtained on study day 1 or 2 from patients enrolled in the United States ALF Study Group with indeterminate (n = 51), pregnancy-related (n = 12), and HSV-related (n = 4) ALF were screened for HSV DNA by PCR and serology. While 7 of the indeterminate and pregnant patients had positive anti-HSV immunoglobulin M, none had detectable HSV DNA. The 4 known HSV cases all had high-titer HSV DNA on presentation (range: 3.5 to 36 x 10(8) copies/mL). Two HSV patients underwent LT but developed posttransplant extrahepatic HSV infection despite suppression of HSV DNA with acyclovir treatment, and one of them eventually died. The 2 other fulminant HSV patients died within 48 hours of presentation. In conclusion, serum HSV DNA indicative of occult HSV infection was not detected in 51 indeterminate and 12 pregnancy-related ALF patients. The 4 patients with known HSV-related ALF all had high HSV DNA levels at presentation, and despite the rapid use of antiviral therapy and emergency LT, substantial morbidity and mortality were encountered, highlighting the poor prognosis with severe disseminated HSV infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.