Evidence map›Paper›PMID 18825487›Full record

ArticleJournal of human genetics2008

Molecular basis of complement factor I (CFI) polymorphism: one of two polymorphic suballeles responsible for CFI A is Japanese-specific.

Isao Yuasa, Mayumi Nakagawa, Kazuo Umetsu, Shinji Harihara, Aya Matsusue, Hiroaki Nishimukai, Yasuo Fukumori, Naruya Saitou, Kyung Sook Park, Feng Jin and 4 more

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In one paragraph

Article in Journal of human genetics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. FHR-5 Serum Levels andFrontiers in immunology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 4 countries.

Isao YuasaDivision of Legal Medicine, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. yuasai@med.tottori-u.ac.jp.
Mayumi NakagawaDepartment of Pathobiological Science and Technology, Faculty of Medicine, Tottori University, Yonago, Japan.
Kazuo UmetsuDepartment of Experimental and Forensic Pathology, Faculty of Medicine, Yamagata University, Yamagata, Japan.
Shinji HariharaDepartment of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.
Aya MatsusueDepartment of Forensic Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Hiroaki NishimukaiDivision of Legal Medicine, Ehime University School of Medicine, Ehime, Japan.
Yasuo FukumoriOsaka Red Cross Blood Center, Osaka, Japan.
Naruya SaitouDivision of Population Genetics, National Institute of Genetics, Mishima, Japan.
Kyung Sook ParkDepartment of Biology, Sungshin Women's University, Seoul, South Korea.
Feng JinInstitute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Gérard LucotteCenter of Molecular Neurogenetics, Paris, France.
Prasanta K ChattopadhyayAmity Institute of Forensic Sciences, Defence Colony, New Delhi, India.
Lotte HenkeInstitut für Blutgruppenforschung, Cologne, Germany.
Jürgen HenkeInstitut für Blutgruppenforschung, Cologne, Germany.
ISG Institute for Social Research · DETottori University · JPChinese Academy of Sciences · CNEhime University · JPFukuoka University · JPNational Institute of Genetics · JPOsaka Red Cross Hospital · JPSungshin Women's University · KRThe University of Tokyo · JPYamagata University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Isoelectric focusing has revealed that human complement factor I (CFI) is controlled by two polymorphic alleles, CFI(*)A and CFI(*)B, and a few rare variant alleles. In this study the molecular basis of the CFI polymorphism was investigated in 174 Japanese. The CFI(*)A was divided into two suballeles, CFI(*)As (R201S) and CFI(*)Ah (R406H). CFI(*)Aj, a rare variant allele originating from CFI(*)Ah, had an additional mutation (R502L). The distribution of these three mutations and two registered SNPs was investigated in a total of 2,471 individuals in 20 populations from various areas, and six haplotypes were observed. Haplotype H3, which is characterized by CFI(*)As, was found only in Far East populations: the frequencies were about 0.03 in the main island of Japan and lower than 0.01 in Okinawa and Korea. Haplotype H5, characterized by CFI(*)Ah, prevailed almost exclusively in East Asians and was observed at the highest frequencies in southern Chinese Han and Thais. CFI(*)Ah must have arisen in a southeastern part of Asia and thereafter have spread to neighboring populations.

Indexed as

AllelesComplement Factor IGenetics, PopulationHaplotypesHumansJapanMutationPolymorphism, Single NucleotideComplement Factor I

Identifiers

PMID18825487
OpenAlexW2016944155

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.