ArticleJournal of neurology2008
Sensory loss, pains, motor deficit and axonal regeneration in length-dependent diabetic polyneuropathy.
Article in Journal of neurology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Preclinical Evidence of Extracellular Vesicle-derived MicroRNAs in Relieving Diabetic Peripheral Neuropathy: A Systematic Review.Journal of molecular neuroscience : MN · 2026Pooled it
- Peripheral Nerve Surgery and Chemotherapy: A Review, Index, and Decision Tree for Nerve Surgeons Considering Neurotization After Oncological Nerve Injuries.Neurosurgery practice · 2026Review
- Association of Nerve Conduction Study Variables with Hematologic Tests in Patients with Type 2 Diabetes Mellitus.Medicina (Kaunas, Lithuania) · 2025Article
- Exploring the role of miRNA in diabetic neuropathy: from diagnostics to therapeutics.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Navigating Preclinical Models and Medications for Peripheral Neuropathy: A Review.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Discontinuity third harmonic generation microscopy for label-free imaging and quantification of intraepidermal nerve fibers.Cell reports methods · 2024Article
- Frontiers in diagnostic and therapeutic approaches in diabetic sensorimotor neuropathy (DSPN).Frontiers in endocrinology · 2023Review
- Application of SygenBioengineering (Basel, Switzerland) · 2022Review
- Review
- Small Fiber Neuropathy in Diabetes Polyneuropathy: Is It Time to Change?Journal of diabetes science and technology · 2022Review
- Diabetic Peripheral Neuropathy.Handbook of experimental pharmacology · 2022Article
- Myelination, axonal loss and Schwann cell characteristics in axonal polyneuropathy compared to controls.PloS one · 2021Article
- Sensorimotor and pain-related alterations of the gray matter and white matter in Type 2 diabetic patients with peripheral neuropathy.Human brain mapping · 2020Article
- Advances with Long Non-Coding RNAs in Diabetic Peripheral Neuropathy.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Small Fiber Neuropathy: Clinicopathological Correlations.Behavioural neurology · 2020Article
- Diabetic neuropathic pain: Physiopathology and treatment.World journal of diabetes · 2015Review
- c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy.Brain : a journal of neurology · 2014Article
- Diabetic plasticity of non-adrenergic non-cholinergic and P2X-mediated rat bladder contractions.Brain research bulletin · 2013Article
- Role of lipotoxicity in endothelial dysfunction.Heart failure clinics · 2012Review
- Diabetic neuropathy: cellular mechanisms as therapeutic targets.Nature reviews. Neurology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to learn more on the occurrence of pains and motor deficit in severe diabetic polyneuropathy we reviewed the data of a series of 30 diabetic patients with an uncommonly severe length-dependent diabetic polyneuropathy (LDDP). Extensive sensory loss predominated with pains and temperature sensations and affected all four limb extremities, anterior trunk in all, plus the top of the scalp in 9 patients and the cauda equina territory in 2. Twenty patients had neuropathic pains. Symptomatic autonomic dysfunction was present in 28/30 patients, mild distal motor deficit in 12 patients, severe in only one. Vibratory sensation was impaired in the lower limbs in 18 patients; position sense in 8. In the 10 nerve biopsy specimens, the density of myelinated axons was reduced to 23 % and that of unmyelinated axons to 8.5 % of control values. Regenerating axons accounted for 32.4 +/- 19.8 % of the myelinated fibres. On teased fibre preparations 13.9 % of fibres were undergoing axonal degeneration, while 29.4 % of fibres showed focal abnormalities of the myelin sheath.We conclude that distal motor deficit occurs only after major loss of sensory fibres in LDDP; the unmyelinated axons are predominantly affected; absence of clinical improvement contrasts with the high proportion of regenerating axons; detection of alteration of pain and temperature sensation in the feet seems the best method for neuropathy screening in diabetic patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.