Trial reportPsychopharmacology2009
Evidence for modulation of facial emotional processing bias during emotional expression decoding by serotonergic and noradrenergic antidepressants: an event-related potential (ERP) study.
Trial report in Psychopharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Beta receptor-mediated modulation of the late positive potential in humans.Psychopharmacology · 2012Trial
- Little evidence for a reduced late positive potential to unpleasant stimuli in major depressive disorder.Neuroimage. Reports · 2022Article
- Attentional Bias Deficits in Adolescent Suicide Attempters During an Emotional Stroop Task: An ERP Study.Frontiers in psychiatry · 2021Article
- Approach and Avoidance Behavior in Female Patients With Borderline Personality Disorder.Frontiers in behavioral neuroscience · 2020Article
- Attenuated LPP to Emotional Face Stimuli Associated with Parent- and Self-Reported Depression in Children and Adolescents.Journal of abnormal child psychology · 2019Article
- Neuroticism predicts the impact of serotonin challenges on fear processing in subgenual anterior cingulate cortex.Scientific reports · 2018Article
- Neural processing of fearful and happy facial expressions during emotion-relevant and emotion-irrelevant tasks: A fixation-to-feature approach.Biological psychology · 2016Article
- The NMDA antagonist ketamine and the 5-HT agonist psilocybin produce dissociable effects on structural encoding of emotional face expressions.Psychopharmacology · 2013Article
- Does coffee enriched with chlorogenic acids improve mood and cognition after acute administration in healthy elderly? A pilot study.Psychopharmacology · 2012Article
- Serotonin at the level of the amygdala and orbitofrontal cortex modulates distinct aspects of positive emotion in primates.The international journal of neuropsychopharmacology · 2012Article
- Differential modulation of emotion processing brain regions by noradrenergic and serotonergic antidepressants.Psychopharmacology · 2011Article
- The modification of attentional bias to emotional information: A review of the techniques, mechanisms, and relevance to emotional disorders.Cognitive, affective & behavioral neuroscience · 2010Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSerotonergic (SSRI) and noradrenergic (NRI) antidepressants modulate biases in emotional processing such that perceptual bias is shifted away from negative and towards positive emotional material. However, the effects of serotonergic and noradrenergic modulation on the temporal course (occurring in milliseconds) of emotional processing, and in particular, the rapid physiological changes associated with the different stages of emotional processing, are unknown.
objectiveThe current study assessed the effects of acute serotonergic (i.e. with citalopram) and noradrenergic (i.e. with reboxetine) augmentation on event-related potential (ERP) measures associated with 'structural encoding' (N170) and emotion expression decoding (N250 and late positive potential [LPP]) for positive (happy) and negative (sad) facial stimuli relative to neutral facial stimuli. MATERIALS AND
methodsThis study employed a double-blind, placebo-controlled, cross-over design in which 12 healthy male participants completed a facial expression recognition task tested under three acute conditions: (a) placebo, (b) citalopram (20 mg) and (c) reboxetine (4 mg).
resultsBoth citalopram and reboxetine had no effect on the N170 ERP component associated with structural encoding, but potentiated the N250 associated with happy (relative to neutral) emotional facial expression decoding. Both drugs had no valence effects on later ERP measures of emotion expression decoding (LPP).
conclusionsCitalopram and reboxetine have selective effects on the temporal course of emotional processing with evidence to suggest specific effects on emotion expression decoding of positive (happy) emotional facial stimuli as evidenced by changes in the attention-modulated N250 but not structural encoding. These findings provide physiological evidence that antidepressants may shift perceptual biases in emotional processing away from negative and towards positive stimuli.
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Registered trials
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