ReviewHandbook of experimental pharmacology2009
Cough sensors. I. Physiological and pharmacological properties of the afferent nerves regulating cough.
Review in Handbook of experimental pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- [Consensus statement on the evaluation and therapy of chronic cough in children].Wiener klinische Wochenschrift · 2014Guideline
- Assessment of Pharmacokinetic Interaction Between Gefapixant (MK-7264), a P2X3 Receptor Antagonist, and the OATP1B1 Drug Transporter Substrate Pitavastatin.Clinical pharmacology in drug development · 2022Article
- Neural control of the lower airways: Role in cough and airway inflammatory disease.Handbook of clinical neurology · 2022Review
- Sensory Innervation of the Larynx and the Search for Mucosal Mechanoreceptors.Journal of speech, language, and hearing research : JSLHR · 2021Article
- Differential effects of acute cerebellectomy on cough in spontaneously breathing cats.PloS one · 2021Article
- Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities.PloS one · 2021Article
- Methods for assessing cough sensitivity.Journal of thoracic disease · 2020Review
- Cough as a Cause and Consequence of Heart Dysfunction - Current State of Art.Physiological research · 2020Review
- Sympatho-excitatory response to pulmonary chemosensitive spinal afferent activation in anesthetized, vagotomized rats.Physiological reports · 2018Article
- Voluntary upregulation of reflex cough is possible in healthy older adults and Parkinson's disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- Oxidative stress as activators of sensory nerves for cough.Pulmonary pharmacology & therapeutics · 2015Review
- Respiratory kinematic and airflow differences between reflex and voluntary cough in healthy young adults.Frontiers in physiology · 2015Article
- Review
- Antitussive drugs--past, present, and future.Pharmacological reviews · 2014Review
- Effect of acid suppression therapy on gastroesophageal reflux and cough in idiopathic pulmonary fibrosis: an intervention study.Cough (London, England) · 2014Article
- Selective inhibition of vagal afferent nerve pathways regulating cough using Nav 1.7 shRNA silencing in guinea pig nodose ganglia.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Refractory chronic cough, or the need to focus on the relationship between the larynx and the esophagus.Cough (London, England) · 2013Article
- Molecular signaling and targets from itch: lessons for cough.Cough (London, England) · 2013Article
- Quantifying nerve architecture in murine and human airways using three-dimensional computational mapping.American journal of respiratory cell and molecular biology · 2013Article
- Transient receptor potential channels mediate the tussive response to prostaglandin E2 and bradykinin.Thorax · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The afferent nerves regulating cough have been reasonably well defined. The selective effects of general anesthesia on C-fiber-dependent cough and the opposing effects of C-fiber subtypes in cough have led to some uncertainty about their regulation of this defensive reflex. But a role for C-fibers in cough seems almost certain, given the unique pharmacological properties of these unmyelinated vagal afferent nerves and the ability of many C-fiber-selective stimulants to evoke cough. The role of myelinated laryngeal, tracheal, and bronchial afferent nerve subtypes that can be activated by punctate mechanical stimuli, inhaled particulates, accumulated secretions, and acid has also been demonstrated. These "cough receptors" are distinct from the slowly and rapidly adapting intrapulmonary stretch receptors responding to lung inflation. Indeed, intrapulmonary rapidly and slowly adapting receptors and pulmonary C-fibers may play no role or a nonessential role in cough, or might even actively inhibit cough upon activation. A critical review of the studies of the afferent nerve subtypes most often implicated in cough is provided.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.