ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009
High prevalence of vitamin K and D deficiency and decreased BMD in inflammatory bowel disease.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Vitamin D deficiency associated with Crohn's disease and ulcerative colitis: a meta-analysis of 55 observational studies.Journal of translational medicine · 2019Pooled it
- Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old.Journal of Korean medical science · 2011Trial
- Review
- Dietary vitamin K intakes, chronic obstructive pulmonary disease, adult asthma, and lung function: a prospective cohort study in the UK Biobank.The American journal of clinical nutrition · 2026Article
- Adult-onset Vitamin K-dependent Coagulation Factor Deficiency of Unidentified Etiology.Internal medicine (Tokyo, Japan) · 2026Article
- Gut, bone, and muscle: the triad of osteosarcopenia in inflammatory bowel disease.Intestinal research · 2025Review
- Hypercoagulability identified in dogs with chronic enteropathy using a point-of-care viscoelastic assay.The Journal of small animal practice · 2025Article
- Nutritional Deficiencies and Reduced Bone Mineralization in Ulcerative Colitis.Journal of clinical medicine · 2025Review
- Vitamin K deficiency as a cause of oral bleeding in a dog with intestinal malabsorption due to lymphocytic-plasmacytic enteritis.Open veterinary journal · 2025Article
- Old Scars, New Bleeds: Revisiting Coagulopathy in Quiescent Crohn's Disease.European journal of case reports in internal medicine · 2025Article
- Development and Validation of Predictive Models for Inflammatory Bowel Disease Diagnosis: A Machine Learning and Nomogram-Based Approach.Journal of inflammation research · 2025Article
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
- High prevalence of vitamin D deficiency in Taiwanese patients with inflammatory bowel disease.Scientific reports · 2024Article
- Low Vitamin K Status in Patients with Psoriasis Vulgaris: A Pilot Study.Biomedicines · 2024Article
- Multiple electrolytes imbalances in a patient with inflammatory bowel disease associated with vitamin D deficiency: a case report.Journal of medical case reports · 2024Article
- The clinical features and risk factors of coagulopathy associated with cefoperazone/sulbactam: a nomogram prediction model.Frontiers in pharmacology · 2024Article
- Low Vitamin K and Vitamin D Dietary Intake in Patients with Inflammatory Bowel Diseases.Nutrients · 2023Article
- Ameliorating Effects of Vitamin K2 on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.International journal of molecular sciences · 2023Article
- Comprehensive Phenotyping in Inflammatory Bowel Disease: Search for Biomarker Algorithms in the Transkingdom Interactions Context.Microorganisms · 2022Article
- Mouse feeding study and microbiome analysis of sourdough bread for evaluation of its health effects.Frontiers in microbiology · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
summaryVitamin K and D deficiency and decreased bone mineral density (BMD) were highly prevalent in patients with inflammatory bowel disease (IBD), especially Crohn's disease (CD). Dietary intakes of these vitamins, however, were above the Japanese adequate intakes in IBD patients, suggesting that malabsorption is the basis for hypovitaminosis K and D and decreased BMD.
introductionWe have studied the possible involvement of vitamin K and D deficiency in the pathogenesis of decreased BMD in IBD.
methodsSeventy patients with IBD were evaluated for their BMD; plasma levels of vitamin K; phylloquinone (PK), menaquinone-7 (MK-7), and 25OH-D; serum PTH, protein induced by vitamin K absence (PIVKA-II), and undercarboxylated osteocalcin (ucOC) levels; and their food intake.
resultsCompared with ulcerative colitis (UC) patients, CD patients had significantly lower plasma vitamin K and 25OH-D concentrations; significantly higher serum levels of PTH, PIVKA-II, and ucOC; and significantly lower BMD scores at almost all measurement sites. More IBD patients were vitamin K deficient in bone than in liver. Multiple regression analyses revealed that low plasma concentrations of vitamin K and 25OH-D were independent risk factors for low BMD and that they were associated with the patients' fat intake, but not with their intake of these vitamins.
conclusionIBD patients have high prevalence of decreased BMD and vitamin K and D deficiency probably caused by malabsorption of these vitamins.
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