ArticleOptics express2008
Dynamic functional and mechanical response of breast tissue to compression.
Article in Optics express, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Errors Induced by Partial Pathlength Variations Due to Mammographic Compression in Dynamic Diffuse Optical Breast Imaging.Proceedings of SPIE--the International Society for Optical Engineering · 2025Article
- In vivo optimization of the experimental conditions for the non-invasive optical assessment of breast density.Scientific reports · 2024Article
- Functional hemodynamic imaging markers for the prediction of pathological outcomes in breast cancer patients treated with neoadjuvant chemotherapy.Journal of biomedical optics · 2024Article
- Mechanical and hemodynamic responses of breast tissue under mammographic-like compression during functional dynamic optical imaging.Biomedical optics express · 2020Article
- Influence of breast compression pressure on the performance of population-based mammography screening.Breast cancer research : BCR · 2017Article
- Feasibility of spatial frequency-domain imaging for monitoring palpable breast lesions.Journal of biomedical optics · 2017Article
- Multimodal breast cancer imaging using coregistered dynamic diffuse optical tomography and digital breast tomosynthesis.Journal of biomedical optics · 2017Article
- Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI).Biomedical optics express · 2017Article
- Blood-pressure-induced oscillations of deoxy- and oxyhemoglobin concentrations are in-phase in the healthy breast and out-of-phase in the healthy brain.Journal of biomedical optics · 2016Article
- Effects of breast density and compression on normal breast tissue hemodynamics through breast tomosynthesis guided near-infrared spectral tomography.Journal of biomedical optics · 2016Article
- Finite-element modeling of compression and gravity on a population of breast phantoms for multimodality imaging simulation.Medical physics · 2016Article
- Broadband optical mammography instrument for depth-resolved imaging and local dynamic measurements.The Review of scientific instruments · 2016Article
- Article
- Enhanced resting-state dynamics of the hemoglobin signal as a novel biomarker for detection of breast cancer.Medical physics · 2015Article
- Macroscopic optical physiological parameters correlate with microscopic proliferation and vessel area breast cancer signatures.Breast cancer research : BCR · 2015Article
- Efficient and optimized identification of generalized Maxwell viscoelastic relaxation spectra.Journal of the mechanical behavior of biomedical materials · 2015Article
- Pain-preventing strategies in mammography: an observational study of simultaneously recorded pain and breast mechanics throughout the entire breast compression cycle.BMC women's health · 2015Observational
- Blood flow reduction in breast tissue due to mammographic compression.Academic radiology · 2014Article
- Towards non-invasive characterization of breast cancer and cancer metabolism with diffuse optics.PET clinics · 2013Article
- Hemodynamic signature of breast cancer under fractional mammographic compression using a dynamic diffuse optical tomography system.Biomedical optics express · 2013Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Physiological tissue dynamics following breast compression offer new contrast mechanisms for evaluating breast health and disease with near infrared spectroscopy. We monitored the total hemoglobin concentration and hemoglobin oxygen saturation in 28 healthy female volunteers subject to repeated fractional mammographic compression. The compression induces a reduction in blood flow, in turn causing a reduction in hemoglobin oxygen saturation. At the same time, a two phase tissue viscoelastic relaxation results in a reduction and redistribution of pressure within the tissue and correspondingly modulates the tissue total hemoglobin concentration and oxygen saturation. We observed a strong correlation between the relaxing pressure and changes in the total hemoglobin concentration bearing evidence of the involvement of different vascular compartments. Consequently, we have developed a model that enables us to disentangle these effects and obtain robust estimates of the tissue oxygen consumption and blood flow. We obtain estimates of 1.9+/-1.3 micromol/100 mL/min for OC and 2.8+/-1.7 mL/100 mL/min for blood flow, consistent with other published values.
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Registered trials
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