ArticleCirculation2008
Loss of myocardial ischemic postconditioning in adenosine A1 and bradykinin B2 receptors gene knockout mice.
Article in Circulation, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 72 citations in OpenAlex.
- Adenosine and adenosine receptors: a "double-edged sword" in cardiovascular system.Frontiers in pharmacology · 2025Review
- Ischemic Postconditioning Reduces Reperfusion Arrhythmias by Adenosine Receptors and Protein Kinase C Activation but Is Independent of KInternational journal of molecular sciences · 2019Article
- Cardioprotection of PLGA/gelatine cardiac patches functionalised with adenosine in a large animal model of ischaemia and reperfusion injury: A feasibility study.Journal of tissue engineering and regenerative medicine · 2019Article
- Roles of Endoplasmic Reticulum Stress in NECA-Induced Cardioprotection against Ischemia/Reperfusion Injury.Oxidative medicine and cellular longevity · 2017Article
- ADORA2b Signaling in Cardioprotection.Journal of nature and science · 2016Article
- Inosine and hypoxanthine as novel biomarkers for cardiac ischemia: from bench to point-of-care.Experimental biology and medicine (Maywood, N.J.) · 2015Review
- In Vivo Effects of Bradykinin B2 Receptor Agonists with Varying Susceptibility to Peptidases.Frontiers in pharmacology · 2015Article
- Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling.Cellular signalling · 2015Article
- Inhibition of PKC-θ preserves cardiac function and reduces fibrosis in streptozotocin-induced diabetic cardiomyopathy.British journal of pharmacology · 2014Article
- Role of P2X7 purinoceptors in neuroprotective mechanism of ischemic postconditioning in mice.Molecular and cellular biochemistry · 2014Article
- Myocardial ischemic conditioning: Physiological aspects and clinical applications in cardiac surgery.Journal of the Saudi Heart Association · 2014Review
- Endogenous cardioprotection by ischaemic postconditioning and remote conditioning.Cardiovascular research · 2012Article
- Type 2 diabetic obese db/db mice are refractory to myocardial ischaemic post-conditioning in vivo: potential role for Hsp20, F1-ATPase δ and Echs1.Journal of cellular and molecular medicine · 2012Article
- Protective effect of ischemic postconditioning against ischemia reperfusion-induced myocardium oxidative injury in IR rats.Molecules (Basel, Switzerland) · 2012Article
- Passive targeting of ischemic-reperfused myocardium with adenosine-loaded silica nanoparticles.International journal of nanomedicine · 2012Article
- MicroRNAs: new players in cardiac injury and protection.Molecular pharmacology · 2011Review
- Endothelial NOS activity and myocardial oxygen metabolism define the salvageable ischemic time window for ischemic postconditioning.American journal of physiology. Heart and circulatory physiology · 2011Article
- The role of muscarinic receptors in the beneficial effects of adenosine against myocardial reperfusion injury in rats.PloS one · 2011Article
- Both A2a and A2b adenosine receptors at reperfusion are necessary to reduce infarct size in mouse hearts.American journal of physiology. Heart and circulatory physiology · 2010Article
- Hypoxia inducible factor 1 (HIF-1) and cardioprotection.Acta pharmacologica Sinica · 2010Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIschemic postconditioning (PostC) is a recently described cardioprotective modality against reperfusion injury, through series of brief reflow interruptions applied at the very onset of reperfusion. It is proposed that PostC can activate a complex cellular signaling cascade, in which cell membrane receptors could serve as the upstream triggers of PostC. However, the exact subtypes of such receptors remain controversial or uninvestigated. To this context, the purpose of present study was to determine the definitive role of adenosine A(1) and bradykinin B(1) and B(2) receptors in PostC. METHODS AND
resultsThe hearts isolated from adult male C57BL/6J wild-type mice or the mice lacking adenosine A(1), or bradykinin B(1) or B(2) receptors subjected to zero-flow global ischemia and reperfusion in a Langendorff model. PostC, consisting of 6 cycles of 10 seconds of reperfusion and 10 seconds of ischemia, demonstrated significantly reduced myocardial infarct size (22.8+/-3.1%, mean+/-SEM) as compared with the non-PostC wild-type controls (35.1+/-2.8%, P<0.05). The infarct-limiting protection of PostC was absent in adenosine A(1) receptor knockout mice (34.9+/-2.7%) or bradykinin B(2) receptor knockout mice (33.3+/-1.7%) and was partially attenuated in bradykinin B(1) receptor-deficient mice (25.6+/-2.9%; P>0.05). On the other hand, PostC did not significantly alter postischemic cardiac contractile function and coronary flow.
conclusionsWith the use of three distinctive strains of gene knockout mice, the current study has provided the first conclusive evidence showing PostC-induced infarct-limiting cardioprotection could be triggered by activation of multiple types of cell membrane receptors, which include adenosine A(1) and bradykinin B(2) receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.