ArticleProceedings of the National Academy of Sciences of the United States of America2008
Structural basis for RNA recognition by a type II poly(A)-binding protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- A role of protein conformational dynamics in mammalian DNA methylation.Structural dynamics (Melville, N.Y.) · 2026Review
- Article
- Oligomeric transition and dynamics of RNA binding by the HuR RRM1 domain in solution.Journal of biomolecular NMR · 2018Article
- mRNA Interactome Capture from Plant Protoplasts.Journal of visualized experiments : JoVE · 2017Article
- The nuclear poly(A) binding protein of mammals, but not of fission yeast, participates in mRNA polyadenylation.RNA (New York, N.Y.) · 2017Article
- UV crosslinked mRNA-binding proteins captured from leaf mesophyll protoplasts.Plant methods · 2016Article
- Conformational stability of the RNP domain controls fibril formation of PABPN1.Protein science : a publication of the Protein Society · 2015Article
- PABPN1 suppresses TDP-43 toxicity in ALS disease models.Human molecular genetics · 2015Article
- cDNA Library Screening Identifies Protein Interactors Potentially Involved in Non-Telomeric Roles of Arabidopsis Telomerase.Frontiers in plant science · 2015Article
- PABPN1: molecular function and muscle disease.The FEBS journal · 2013Review
- Polyalanine-independent conformational conversion of nuclear poly(A)-binding protein 1 (PABPN1).The Journal of biological chemistry · 2012Article
- Structure of the heterodimer of human NONO and paraspeckle protein component 1 and analysis of its role in subnuclear body formation.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Comparative in silico analyses of cpeb1-4 with functional predictions.Bioinformatics and biology insights · 2010Article
- Hsp70 chaperones and type I PRMTs are sequestered at intranuclear inclusions caused by polyalanine expansions in PABPN1.PloS one · 2009Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
We identified a functional domain (XlePABP2-TRP) of Xenopus laevis embryonic type II poly(A)-binding protein (XlePABP2). The NMR structure of XlePABP2-TRP revealed that the protein is a homodimer formed by the antiparallel association of beta-strands from the single RNA recognition motif (RRM) domain of each subunit. In each subunit of the homodimer, the canonical RNA recognition site is occluded by a polyproline motif. Upon poly(A) binding, XlePABP2-TRP undergoes a dimer-monomer transition that removes the polyproline motif from the RNA recognition site and allows it to be replaced by the adenosine nucleotides of poly(A). Our results provide high-resolution structural information concerning type II PABPs and an example of a single RRM domain protein that transitions from a homodimer to a monomer upon RNA binding. These findings advance our understanding of RRM domain regulation, poly(A) recognition, and are relevant to understanding how type II PABPs function in mRNA processing and human disease.
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Registered trials
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